Korean J Urol.  1960 Oct;1(2):111-117.

Influence of Hepatic Damage on the Male Reproductive Glands: IV. Effect of Cortisone on the Reproductive Glands of Male White Rats with Liver Damage

• Kim YK
• Lee HS

Abstract

Young adult male rats were injected with carbon tetrachloride along with cortisone acetate simultaneously and the effect of cortisone acetate on the damage of the liver and the liver's effect on the reproductive gland and its accessories were studied. The following results were obtained: Cortisone acetate given rats with damaged livers caused a very remarkable decrease in the weights of the accessory glands of reproduction, while the liver was restored to normal hepatic architecture. Judging from the marked weight decreases of the glands, cortisone acetate is thought to be responsible for enhancing the estrogenic effect through liver dysfunction despite the return to normal hepatic histology. Citric acid concentration in the prostatic tissue was not altered greatly by cortisone acetate administration. The concentration of the prostatic citrate can not be taken as an index of androgenic activity.

Keyword

liver cirrhosis; cortisone; male reproductive glan

MeSH Terms

Animals
Carbon Tetrachloride
Citric Acid
Cortisone*
Estrogens
Humans
Liver Cirrhosis
Liver Diseases
Liver*
Male*
Rats*
Reproduction
Weights and Measures
Young Adult
Carbon Tetrachloride
Citric Acid
Cortisone
Estrogens