Lab Anim Res.  2011 Dec;27(4):369-371. 10.5625/lar.2011.27.4.369.

Antifibrotic activity a fermentation filtrate of Ganoderma lucidum

• Kwon SC
• Kim YB

• KMID: 1444974
• DOI: http://doi.org/10.5625/lar.2011.27.4.369

Abstract

The effects of a fermentation filtrate of Ganoderma lucidum (FGL) on carbon tetrachloride (CCl4)-induced hepatic fibrosis were investigated in rats. Male Sprague-Dawley rats were orally administered with FGL (20 or 100 mg/kg) for 33 days, and orally administered with CCl4 (1.0 mL/kg; 2 mL/kg of 50% in corn oil) at 3-day intervals 1 h after FGL treatment. Body and liver weights, blood and histopathological findings in accordance with hydroxyproline concentrations were analyzed. Chronic exposure to CCl4 reduced the body weight gain, but increased liver weights and fibrosis, resulting in 3.35-fold increase in hydroxyproline level. Although FGL did not significantly reduce the CCl4-induced body and liver weight changes, it attenuated the increases in the hepatic fibrosis and hydroxyproline contents. Taken together, it is suggested that FGL might prevent hepatic fibrosis, and that FGL or its ingredient could be a potential candidate for the prevention of chronic hepatic disorders.

Keyword

Carbon tetrachloride (CCl4); hepatic fibrosis; Ganoderma lucidum; fermentation filtrate

MeSH Terms

Animals
Body Weight
Carbon Tetrachloride
Fermentation
Fibrosis
Ganoderma
Humans
Hydroxyproline
Liver
Male
Rats
Rats, Sprague-Dawley
Reishi
Weights and Measures
Zea mays
Carbon Tetrachloride
Hydroxyproline

Figure

• 

  Figure 1 Change in body weights of rats administered with carbon tetrachloride (CCl4; 1 mL/kg) for 33 days at 3-day intervals and/or a fermentation filtrate of Ganoderma lucidum (FGL; 20 or 100 mg/kg daily). ○, normal; •, CCl4 alone; ▾, CCl4+20 mg/kg FGL; ▪, CCl4+100 mg/kg FGL.

• 

  Figure 2 Representative hepatic fibrosis of the liver of rats administered with carbon tetrachloride (CCl4, 1 mL/kg) for 33 days at 3-day intervals and/or a fermentation filtrate of Ganoderma lucidum (FGL; 20 or 100 mg/kg daily). A, normal; B, CCl4 alone; C, CCl4+20 mg/kg FGL; D, CCl4+100 mg/kg FGL.

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