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A Rare Case of Phyllodes Tumor Metastasis to the Stomach Presenting as Anemia

Choi DI, Chi HS, Lee SH, Kwon Y, Park SY, Sim SH, Park IH, Lee KS

  • Cancer Res Treat.
  • 2017 Jul;49(3):846-849.
  • doi: 10.4143/crt.2016.188
Metastasis of a phyllodes tumor to the stomach is an extremely rare condition with important clinical implications. A 44-year-old woman was initially diagnosed with a phyllodes tumor in her right...
Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-Analysis

Cremolini , Antoniotti C, Pietrantonio F, Berenato R, Tampellini M, Baratelli , Salvatore , Marmorino , Borelli B, Nichetti F, Bironzo P, Sonetto C, Di Bartolomeo M, de Braud F, Loupakis F, Falcone A, Di Maio M

  • Cancer Res Treat.
  • 2017 Jul;49(3):834-845.
  • doi: 10.4143/crt.2016.249
PURPOSE: The purpose of this study was to evaluate progression-free survival (PFS) and objective response rate (ORR) as surrogate endpoints of overall survival (OS) in modern clinical trials investigating the...
Impact of Resection Margin Distance on Survival of Pancreatic Cancer: A Systematic Review and Meta-Analysis

Kim KS, Kwon J, Kim K, Chie EK

  • Cancer Res Treat.
  • 2017 Jul;49(3):824-833.
  • doi: 10.4143/crt.2016.336
PURPOSE: While curative resection is the only chance of cure in pancreatic cancer, controversies exist about the impact of surgical margin status on survival. Non-standardized pathologic report and different criteria...
A Randomized Phase II Study of Leucovorin/5-Fluorouracil with or without Oxaliplatin (LV5FU2 vs. FOLFOX) for Curatively-Resected, Node-Positive Esophageal Squamous Cell Carcinoma

Lim SH, Shim YM, Park SH, Kim HK, Choi YS, Ahn MJ, Park K, Zo JI, Sun JM

  • Cancer Res Treat.
  • 2017 Jul;49(3):816-823.
  • doi: 10.4143/crt.2016.417
PURPOSE: The optimal perioperative treatment for resectable esophageal squamous cell carcinoma (ESCC) remains controversial. We evaluated the efficacy and safety of leucovorin and 5-fluorouracil (LV5FU2) and LV5FU2 plus oxaliplatin (FOLFOX)...
CA19-9 or CEA Decline after the First Cycle of Treatment Predicts Survival in Advanced Biliary Tract Cancer Patients Treated with S-1 and Cisplatin Chemotherapy

Lee DW, Im SA, Kim YJ, Yang Y, Rhee J, Na II, Lee KH, Kim TY, Han SW, Choi IS, Oh DY, Kim JH, Kim TY, Bang YJ

  • Cancer Res Treat.
  • 2017 Jul;49(3):807-815.
  • doi: 10.4143/crt.2016.326
PURPOSE: While tumor markers (carbohydrate antigen 19-9 [CA 19-9] and carcinoembryonic antigen [CEA]) can aid in the diagnosis of biliary tract cancer, their prognostic role has not been clearly elucidated....
Trends in Participation Rates for the National Cancer Screening Program in Korea, 2002-2012

Suh M, Song S, Cho HN, Park B, Jun JK, Choi E, Kim Y, Choi KS

  • Cancer Res Treat.
  • 2017 Jul;49(3):798-806.
  • doi: 10.4143/crt.2016.186
PURPOSE: The National Cancer Screening Program (NCSP) in Korea supports cancer screening for stomach, liver, colorectal, breast, and cervical cancer. This study was conducted to assess trends in participation rates...
p15(Ink4b) Loss of Expression by Promoter Hypermethylation Adds to Leukemogenesis and Confers a Poor Prognosis in Acute Promyelocytic Leukemia Patients

Baba SM, Azad NA, Shah ZA, Dil-Afroze , Pandith AA, Jan A, Aziz SA

  • Cancer Res Treat.
  • 2017 Jul;49(3):790-797.
  • doi: 10.4143/crt.2016.108
PURPOSE: The p15(Ink4b) gene exerts its influence as an inhibitor of cyclin-dependent kinases and is frequently associated with hematological malignancies. Inactivation of this gene through DNA methylation has been found...
Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo

Tang JC, An R, Jiang YQ, Yang J

  • Cancer Res Treat.
  • 2017 Jul;49(3):778-789.
  • doi: 10.4143/crt.2015.485
PURPOSE: The purpose of this study was to observe the effects of metformin on human esophageal cancer cell and to investigate its possible mechanisms. MATERIALS AND METHODS: Cell viability was detected...
FGFR4 Arg388 Is Correlated with Poor Survival in Resected Colon Cancer Promoting Epithelial to Mesenchymal Transition

Cho SH, Hong CS, Kim HN, Shin MH, Kim KR, Shim HJ, Hwang JE, Bae WK, Chung IJ

  • Cancer Res Treat.
  • 2017 Jul;49(3):766-777.
  • doi: 10.4143/crt.2016.457
PURPOSE: Fibroblast growth factor receptor 4 (FGFR4) plays an important role in cancer progression during tumor proliferation, invasion, and metastasis. This study evaluated the prognostic role of FGFR4 polymorphism in...
Efficacy of Chemotherapy in Patients with Unresectable or Metastatic Pancreatic Acinar Cell Carcinoma: Potentially Improved Efficacy with Oxaliplatin-Containing Regimen

Yoo C, Kim BJ, Kim KP, Lee JL, Kim TW, Ryoo BY, Chang HM

  • Cancer Res Treat.
  • 2017 Jul;49(3):759-765.
  • doi: 10.4143/crt.2016.371
PURPOSE: Pancreatic acinar cell carcinoma (ACC) is a rare cancer of the exocrine pancreas. Because of its rare incidence, the efficacy of chemotherapy in this patient population has been largely...
Effects of Postoperative Radiotherapy on Leptomeningeal Carcinomatosis or Dural Metastasis after Resection of Brain Metastases in Breast Cancer Patients

Ha B, Chung SY, Kim YJ, Gwak HS, Chang JH, Lee SH, Park IH, Lee KS, Lee S, Kim TH, Kim DY, Kang SG, Suh CO

  • Cancer Res Treat.
  • 2017 Jul;49(3):748-758.
  • doi: 10.4143/crt.2016.303
PURPOSE: In this retrospective study, we compared the incidence of leptomeningeal carcinomatosis or dural metastasis (LMCDM) in patients who received whole brain radiotherapy (WBRT), partial radiotherapy (PRT), or no radiotherapy...
Incorporating Risk Factors to Identify the Indication of Post-mastectomy Radiotherapy in N1 Breast Cancer Treated with Optimal Systemic Therapy: A Multicenter Analysis in Korea (KROG 14-23)

Park HJ, Shin KH, Kim JH, Ahn SD, Kim JY, Park W, Kim YB, Kim YJ, Kim JH, Kim K, Park KR, Shin HS, Jeong BK, Lee SY, Kim S

  • Cancer Res Treat.
  • 2017 Jul;49(3):739-747.
  • doi: 10.4143/crt.2016.405
PURPOSE: In a recent meta-analysis, post-mastectomy radiotherapy (PMRT) reduced any first recurrence (AFR) and improved survival in N1 and N2 patients. We investigated risk factors for AFR in N1 after...
Why Do Some People Choose Opportunistic Rather Than Organized Cancer Screening? The Korean National Health and Nutrition Examination Survey (KNHANES) 2010-2012

Hahm MI, Chen HF, Miller T, O'Neill L, Lee HY

  • Cancer Res Treat.
  • 2017 Jul;49(3):727-738.
  • doi: 10.4143/crt.2016.243
PURPOSE: Although the Korean government has implemented a universal screening program for common cancers, some individuals choose to participate in opportunistic screening programs. Therefore, this study was conducted to identify...
Outcomes of Treatment for Malignant Peripheral Nerve Sheath Tumors: Different Clinical Features Associated with Neurofibromatosis Type 1

Hwang IK, Hahn SM, Kim HS, Kim SK, Kim HS, Shin KH, Suh CO, Lyu CJ, Han JW

  • Cancer Res Treat.
  • 2017 Jul;49(3):717-726.
  • doi: 10.4143/crt.2016.271
PURPOSE: Malignant peripheral nerve sheath tumors (MPNSTs) are a rare subtype of sarcoma that occur spontaneously or in association with neurofibromatosis type 1 (NF-1). This study aimed to clinically differentiate...
A Multicenter Randomized Phase II Study of Docetaxel vs. Docetaxel Plus Cisplatin vs. Docetaxel Plus S-1 as Second-Line Chemotherapy in Metastatic Gastric Cancer Patients Who Had Progressed after Cisplatin Plus Either S-1 or Capecitabine

Lee KW, Kim BJ, Kim MJ, Han HS, Kim JW, Park YI, Park SR

  • Cancer Res Treat.
  • 2017 Jul;49(3):706-716.
  • doi: 10.4143/crt.2016.216
PURPOSE: This study evaluated the re-challenge of S-1 or cisplatin in combination with docetaxel in metastatic gastric cancer (MGC) that had progressed on a cisplatin plus either S-1 or capecitabine...
Clinicopathologic Characteristics and Prognosis of Tongue Squamous Cell Carcinoma in Patients with and without a History of Radiation for Nasopharyngeal Carcinoma: A Matched Case-Control Study

Zhang P, Zhang L, Liu H, Zhao L, Li Y, Shen JX, Liu Q, Liu MZ, Xi M

  • Cancer Res Treat.
  • 2017 Jul;49(3):695-705.
  • doi: 10.4143/crt.2016.317
PURPOSE: Previous studies reported an association between an increased risk of tongue cancer and radiation treatment for nasopharyngeal carcinoma (NPC). This study compared the clinicopathologic characteristics and outcomes of tongue...
Survey of the Patterns of Using Stereotactic Ablative Radiotherapy for Early-Stage Non-small Cell Lung Cancer in Korea

Song S, Chang JH, Kim HJ, Kim YS, Kim JH, Ahn YC, Kim JS, Song SY, Moon SH, Cho MJ, Youn SM

  • Cancer Res Treat.
  • 2017 Jul;49(3):688-694.
  • doi: 10.4143/crt.2016.219
PURPOSE: Stereotactic ablative radiotherapy (SABR) is an effective emerging technique for early-stage non-small cell lung cancer (NSCLC). We investigated the current practice of SABR for early-stage NSCLC in Korea. MATERIALS AND...
ERCC1 Expression-Based Randomized Phase II Study of Gemcitabine/Cisplatin Versus Irinotecan/Cisplatin in Patients with Advanced Non-small Cell Lung Cancer

Han JY, Lee GK, Lim KY, Lee YJ, Nam BH, Lee JS

  • Cancer Res Treat.
  • 2017 Jul;49(3):678-687.
  • doi: 10.4143/crt.2016.365
PURPOSE: We evaluated the clinical utility of excision repair cross-complementation group 1 (ERCC1) expression as a predictive biomarker for platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC). MATERIALS AND METHODS:...
Dose-Response Relationship between Radiation Dose and Loco-regional Control in Patients with Stage II-III Esophageal Cancer Treated with Definitive Chemoradiotherapy

Kim HJ, Suh YG, Lee YC, Lee SK, Shin SK, Cho BC, Lee CG

  • Cancer Res Treat.
  • 2017 Jul;49(3):669-677.
  • doi: 10.4143/crt.2016.354
PURPOSE: The correlation between radiation dose and loco-regional control (LRC) was evaluated in patients with stage II-III esophageal cancer treated with definitive concurrent chemoradiotherapy (CRT). MATERIALS AND METHODS: Medical records of...
Long Non-coding RNA HOXA11 Antisense Promotes Cell Proliferation and Invasion and Predicts Patient Prognosis in Serous Ovarian Cancer

Yim GW, Kim HJ, Kim LK, Kim SW, Kim S, Nam EJ, Kim YT

  • Cancer Res Treat.
  • 2017 Jul;49(3):656-668.
  • doi: 10.4143/crt.2016.263
PURPOSE: The biological function of long non-coding RNAs (lncRNAs) is only partially understood; therefore, in this study, we investigated the expression of the novel HOXA11 antisense (HOXA11as) lncRNA and its...

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