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Influence of Short- and Long-term High-dose Caffeine Administration on Behavior in an Animal Model of Adolescence

Park JM, Kim Y, Kim H, Kim YJ

PURPOSE: Caffeine is the most widely consumed psychostimulant of the methylxanthine class. Among adolescents, high-dose of caffeine consumption has increased rapidly over the last few decades due to the introduction...
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Improved preimplantation development of porcine somatic cell nuclear transfer embryos by caffeine treatment

Kim G, Roy PK, Fang X, Hassan BM, Cho J

This study examined the effects of a caffeine treatment to improve nuclear reprogramming in porcine cloned embryos. Embryonic development and the expression of genes related to pluripotency (POU5F1, SOX2, NANOG,...
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Study on relationship between caffeine intake level and metabolic syndrome and related diseases in Korean adults: 2013 ~ 2016 Korea National Health and Nutrition Examination Survey

Lee JS, Park HS, Han S, Tana G, Chang MJ

PURPOSE: This study examined the relationship between caffeine intake and metabolic syndrome in Korean adults using the 2013 ~ 2016 Korea National Health and Nutrition Examination Survey data (KNHANES). METHODS: The...
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Health Related Nutritional Knowledge and Dietary Behavior Regarding Caffeine Intake among High School Students in Yongin Region

Kim SY

OBJECTIVES: We aimed to examine health-related nutritional knowledge and dietary behavior related to caffeine intake among high school students (n = 310) in the Yongin region of Korea. METHODS: Data were...
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How Much Caffeine is Too Much for Young Adolescents?

Cho HW

No abstract available.
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Hemodynamic Effects on Systemic Blood Flow and Ductal Shunting Flow after Loading Dose of Intravenous Caffeine in Preterm Infants according to the Patency of Ductus Arteriosus

Hwang J, Kim YS, Shin JH, Choi BM

BACKGROUND: In preterm infants, caffeine citrate is used to stimulate breathing before they are weaned from mechanical ventilation and to reduce the frequency of apnea. In recent studies, effects of...
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Attention and Working Memory Task-Load Dependent Activation Increase with Deactivation Decrease after Caffeine Ingestion

Peng W, Zhang J, Chang D, Shen ZW, Shang Y, Song D, Ge Q, Weng X, Wang Z

PURPOSE: Caffeine is the most widely consumed psychostimulant. It is often adopted as a tool to modulate brain activations in fMRI studies. However, its pharmaceutical effect on task-induced deactivation has...
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Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications

Han S, Cho YS, Yoon SK, Kim H, Bae KS

Caffeine is a naturally-occurring central nervous system stimulant found in plant constituents including coffee, cocoa beans, and tea leaves. Consumption of caffeine through imbibing caffeinated drinks is rapidly growing among...
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Intravenous caffeine citrate vs. magnesium sulfate for reducing pain in patients with acute migraine headache; a prospective quasi-experimental study

Baratloo A, Mirbaha S, Delavar Kasmaei H, Payandemehr P, Elmaraezy , Negida A

BACKGROUND: Current evidence suggests that intravenous magnesium sulfate might be effective for reducing migraine pain. In a recent pilot study, we showed that intravenous caffeine citrate could reduce the severity...
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Immediate Decrease in γ-AminoButyric Acid after Caffeine Intake in Adolescents: a Preliminary MRS Study

Hahn S, Kim YH, Seo HS

In adolescents, sleep deprivation problem is getting worse, and increased caffeine consumption is considered to relieve the stress caused by sleep deprivation and academic burden. In this study, immediate neurologic...
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Clinical Pharmacokinetics of Caffeine in Korean Preterm Infants with Apnea of Prematurity

Lim MS, Son MJ, Shin JE, Lee SM, Eun HS, Park MS, Park KI, Namgung R

PURPOSE: Caffeine shows wide interindividual pharmacokinetic (PK) variation, and therapeutic drug monitoring (TDM) may be needed. The PK profile of caffeine in Korean preterm neonates was investigated, and factors influencing...
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Prediction of pharmacokinetics and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach: A case study of caffeine and ciprofloxacin

Park MH, Shin SH, Byeon JJ, Lee GH, Yu BY, Shin YG

Over the last decade, physiologically based pharmacokinetics (PBPK) application has been extended significantly not only to predicting preclinical/human PK but also to evaluating the drug-drug interaction (DDI) liability at the...
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Relationships between job stress and caffeine intake in industrial workers

Yim JS, Lee JJ

PURPOSE: This study analyzed the degree of job stress and caffeine intake in workers in industrial positions in order to determine the relationships between job stress and caffeine intake. METHODS: For...
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Pharmacokinetic Interaction of Chrysin with Caffeine in Rats

Noh K, Oh DG, Nepal MR, Jeong KS, Choi Y, Kang MJ, Kang W, Jeong HG, Jeong TC

Pharmacokinetic interaction of chrysin, a flavone present in honey, propolis and herbs, with caffeine was investigated in male Sprague-Dawley rats. Because chrysin inhibited CYP1A-selective ethoxyresorufin O-deethylase and methoxyresorufin O-demethylase activities...
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The Relationship of Caffeine Intake with Depression, Anxiety, Stress, and Sleep in Korean Adolescents

Jin MJ, Yoon CH, Ko HJ, Kim HM, Kim AS, Moon HN, Jung SP

BACKGROUND: In various studies in adults, caffeine may increase wakefulness and relieve pain, but caffeine overdose can cause many adverse serious effects on health. Caffeine intake has recently been increasing...
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The Impact of Alcohol and Caffeine Intake on Body Mass Index, Alcohol Use Disorder, and Quality of Sleep among University Freshmen

Cho YH, Cho MK

PURPOSE: The purpose of this study was to assess alcohol and caffeine intake and identify the impact of alcohol and caffeine intake on body mass index, alcohol use disorder, and...
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Efficacy of Slimming Cream Containing 3.5% Water-Soluble Caffeine and Xanthenes for the Treatment of Cellulite: Clinical Study and Literature Review

Byun SY, Kwon SH, Heo SH, Shim JS, Du MH, Na JI

BACKGROUND: Cellulite is a 'cottage cheese-like' cutaneous change caused by subcutaneous fat bulging into the dermis that usually leads to cosmetic problems. Slimming cream containing 3.5% water-soluble caffeine and xanthenes...
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Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats

Noh K, Nepal MR, Jeong KS, Kim SA, Um YJ, Seo CS, Kang MJ, Park PH, Kang W, Jeong HG, Jeong TC

Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia. Because baicalein and baicalin are major components of this herb, it is important to understand the...
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Comparison between Caffeine and Theophylline Therapy for Apnea of Prematurity

Jeong K, Kim HS, Song ES, Choi YY

PURPOSE: Methylxanthines are commonly used to treat apnea of prematurity. Recent studies have reported that caffeine therapy reduces the rate of bronchopulmonary dysplasia (BPD) and improves the rate of survival...
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Anaphylaxis due to caffeine

Sugiyama K, Cho T, Tatewaki M, Onishi S, Yokoyama T, Yoshida N, Fujimatsu , Hirata H, Fukuda T, Fukushima

We report a rare case of anaphylaxis due to caffeine intake. A 27-year-old woman suffered her first episode of anaphylaxis and a positive skin prick test suggested that the anaphylaxis...
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