- The Krüppel-like factor (KLF5) as a predictive biomarker in preoperative chemoradiation therapy for rectal cancer
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Kim JY, Park SG, Kim KS, Choi YH, Kim NK
- KMID: 2455982
- Ann Surg Treat Res.
- 2019 Aug;97(2):83-92.
- doi: 10.4174/astr.2019.97.2.83
PURPOSE: Preoperative chemoradiation therapy (CRT) has become the standard treatment for patients with locally advanced rectal cancer, 15%–30% of patients still progress while being treated with CRT. The aim of... -
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- Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model
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Lei X, Cai L, Li X, Xu H, Geng C, Wang C
- KMID: 2410091
- Korean J Physiol Pharmacol.
- 2018 May;22(3):269-275.
- doi: 10.4196/kjpp.2018.22.3.269
Naâº/H⺠exchangers (NHEs) have been shown to be involved in regulating cell volume and maintaining fluid and electrolyte homeostasis. Pooled evidences have suggested that loss of Naâº/H⺠exchanger isoform 8... -
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- Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
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Chelakkot , Choi Y, Kim DK, Park HT, Ghim J, Kwon Y, Jeon J, Kim MS, Jee YK, Gho YS, Park HS, Kim YK, Ryu SH
- KMID: 2440032
- Exp Mol Med.
- 2018 Feb;50(2):e450.
- doi: 10.1038/emm.2017.282
The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity... -
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- Infection of human intestinal epithelial cells by invasive bacteria activates NF-κB and increases ICAM-1 expression through NOD1
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Shin WG, Park BJ, Lee SJ, Kim JG
- KMID: 2411512
- Korean J Intern Med.
- 2018 Jan;33(1):81-90.
- doi: 10.3904/kjim.2015.409
BACKGROUND/AIMS: Nucleotide-binding oligomerization domain 1 (NOD1) is required for primary intestinal epithelial cells (IECs) to respond to natural mucopeptides secreted by gram-negative bacteria. Infection of human IECs with invasive bacteria... -
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- Elevated folic acid results in contrasting cancer cell line growth with implications for mandatory folic acid fortification
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Yates Z, Lucock M, Veysey M, Choi JH
- KMID: 2209844
- J Nutr Health.
- 2016 Apr;49(2):72-79.
- doi: 10.4163/jnh.2016.49.2.72
PURPOSE: The initiation of mandatory folic acid fortification using pteroylmonoglutamic acid (PteGlu) has reduced the rate of congenital malformations. However, it also appears to be responsible for several adverse effects,... -
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- Postprandial hypoglycemic effects of mulberry twig and root bark in vivo and in vitro
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Park SY, Jin BR, Lee YR, Kim YJ, Park JB, Jeon YH, Choi SW, Kwon O
- KMID: 2158302
- J Nutr Health.
- 2016 Feb;49(1):18-27.
- doi: 10.4163/jnh.2016.49.1.18
PURPOSE: Our previous study demonstrated the hypoglycemic effects of mulberry (Morus alba L.) leaf and the underlying mechanisms. Here we explored the potency of mulberry twigs (TW) and root barks... -
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- Chemopreventive effect of alpha-viniferin in azoxymethane-induced mouse colorectal tumor and Caco-2 cells
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Kwak DH, Shin SK, Youm SY, Kim TW, Kim Y, Ahn B
- KMID: 2286283
- J Biomed Res.
- 2015 Jun;16(2):60-66.
- doi: 10.12729/jbr.2015.16.2.060
alpha-Viniferin (AVF), a trimer of resveratrol, is known to have an anti-inflammatory effect via inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). It has been reported that up-regulated... -
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- Selection and immunomodulatory evaluation of lactic acid bacteria suitable for use as canine probiotics
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Park SM, Park HE, Lee WK
- KMID: 1807795
- Korean J Vet Res.
- 2015 Jun;55(2):81-88.
- doi: 10.14405/kjvr.2015.55.2.81
This study was conducted to isolate lactic acid bacteria (LAB) from dog intestine and identify potential probiotic strains for canine use. One hundred and one LAB were isolated from feces... -
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- Nucleotide Binding Oligomerization Domain 1 Is an Essential Signal Transducer in Human Epithelial Cells Infected with Helicobacter pylori That Induces the Transepithelial Migration of Neutrophils
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Kim BJ, Kim JY, Hwang ES, Kim JG
- KMID: 2155644
- Gut Liver.
- 2015 May;9(3):358-369.
- doi: 10.5009/gnl13218
BACKGROUND/AIMS: The cytosolic host protein nucleotide binding oligomerization domain 1 (Nod1) has emerged as a key pathogen recognition molecule for innate immune responses in epithelial cells. The purpose of the... -
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- Intestinal anti-inflammatory activity of Sasa quelpaertensis leaf extract by suppressing lipopolysaccharide-stimulated inflammatory mediators in intestinal epithelial Caco-2 cells co-cultured with RAW 264.7 macrophage cells
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Kim KM, Kim YS, Lim JY, Min SJ, Ko HC, Kim SJ, Kim Y
- KMID: 2313802
- Nutr Res Pract.
- 2015 Feb;9(1):3-10.
- doi: 10.4162/nrp.2015.9.1.3
BACKGROUND/OBJECTIVES: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, involves chronic inflammation of the gastrointestinal tract. Previously, Sasa quelpaertensis leaves have been shown to mediate anti-inflammation and anti-cancer... -
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- Characteristics and immuno-modulatory effects of Enterococcus faecium JS1-8 isolated from Kimchi
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Ahn SB, Park HE, Lee SM, Kim SY, Lee WK
- KMID: 2168997
- J Biomed Res.
- 2014 Dec;15(4):182-188.
- doi: 10.12729/jbr.2014.15.4.182
Characteristics and immuno-modulatory effects of Enterococcus (E.) faecium JS1-8 isolated from Kimchi were investigated for potential probiotic use. We measured their acid, bile, and heat tolerances, adhesion properties in Caco-2... -
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- Degradation of the Transcription Factors NF-kappaB, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells
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Kim KA, Min A, Lee YA, Shin MH
- KMID: 1792210
- Korean J Parasitol.
- 2014 Oct;52(5):459-469.
- doi: 10.3347/kjp.2014.52.5.459
Entamoeba histolytica is a tissue-invasive protozoan parasite causing dysentery in humans. During infection of colonic tissues, amoebic trophozoites are able to kill host cells via apoptosis or necrosis, both of... -
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- Characteristics and immuno-modulatory effects of Weissella cibaria JW15 isolated from Kimchi, Korea traditional fermented food, for probiotic use
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Ahn SB, Park HE, Lee SM, Kim SY, Shon MY, Lee WK
- KMID: 1703513
- J Biomed Res.
- 2013 Dec;14(4):206-211.
In this study, characteristics and immuno-modulatory effects of Weissella cibaria JW15 isolated from Kimchi, traditional Korean fermented food, were examined for investigation of the capacity of potentially probiotic strains. We... -
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- The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis
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Kim SD, Kwon S, Lee SK, Kook M, Lee HY, Song KD, Lee HK, Baek SH, Park CB, Bae YS
- KMID: 2154259
- Exp Mol Med.
- 2013 Sep;45(9):e40.
In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body... -
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- Zanamivir Oral Delivery: Enhanced Plasma and Lung Bioavailability in Rats
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Shanmugam , Im HT, Sohn YT, Kim KS, Kim YI, Yong CS, Kim JO, Choi HG, Woo JS
- KMID: 1502519
- Biomol Ther.
- 2013 Mar;21(2):161-169.
The objective of this study was to enhance the oral bioavailability (BA) of zanamivir (ZMR) by increasing its intestinal permeability using permeation enhancers (PE). Four different classes of PEs (Labrasol(R),... -
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- Apical acidity decreases inhibitory effect of omeprazole on Mg2+ absorption and claudin-7 and -12 expression in Caco-2 monolayers
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Thongon N, Krishnamra N
- KMID: 1401760
- Exp Mol Med.
- 2012 Nov;44(11):684-693.
Clinical studies reported hypomagnesaemia in long-term omeprazole usage that was probably due to intestinal Mg2+ wasting. Our previous report demonstrated the inhibitory effect of omeprazole on passive Mg2+ transport across... -
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- Adhesion Activity of Lactobacillus plantarum PM 008 Isolated from Kimchi on the Intestine of Mice
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Jang SE, Hyun YJ, Oh YJ, Choi KB, Kim T, Yeo IH, Han MJ, Kim DH
- KMID: 2168625
- J Bacteriol Virol.
- 2011 Jun;41(2):83-90.
- doi: 10.4167/jbv.2011.41.2.83
Lactic acid bacteria (LAB), including L. plantarum isolated from Kimchi, are beneficial and safe microorganisms that improve disturbances of the indigenous microflora and the host's immune system. The adhesion abilities... -
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- Effects of DCA on Cell Cycle Proteins in Colonocytes
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Ha YH, Park DG
- KMID: 2198785
- J Korean Soc Coloproctol.
- 2010 Aug;26(4):254-259.
- doi: 10.3393/jksc.2010.26.4.254
PURPOSE: Evidence that indicates bile acid is a promoter of colon cancer exists. Deoxycholic acid (DCA) modifies apoptosis or proliferation by affecting intracellular signaling and gene expression. However, because previous... -
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- TNF-alpha Downregulates E-cadherin and Sensitizes Response to gamma-irradiation in Caco-2 Cells
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Yi JY, Jung YJ, Choi SS, Chung E
- KMID: 2128578
- Cancer Res Treat.
- 2009 Sep;41(3):164-170.
PURPOSE: The purpose of the present study was to assess the biological effects of TNF-alpha in Caco-2 well-differentiated colon adenocarcinoma cells and to determine radiation sensitivity in order to develop... -
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- Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models
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Park MY, Kwon HJ, Sung MK
- KMID: 2313371
- Nutr Res Pract.
- 2009 Mar;3(1):9-14.
Aloe products are one of the top selling health-functional foods in Korea, however the adequate level of intake to achieve desirable effects are not well understood. The objective of this... -
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