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Ubiquitination of Aquaporin: in the kidney

Lee YJ, Kwon TH

Ubiquitination is known to be important for endocytosis and lysosomal degradation of aquaporin-2 (AQP2). Ubiquitin (Ub) is covalently attached to the lysine residue of the substrate proteins and activation and...
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Vasopressin and Vasopressin Receptor Antagonists

Oh YK

Vasopressin, a neurohypophyseal peptide hormone, is the endogenous agonist at V1a, V1b, and V2 receptors. The most important physiological function of vasopressin is the maintenance of water homeostasis through interaction...
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Role of Nitric Oxide in the Regulation of Aquaporin-2 Water Channels in Rat Kidney

Kim YJ, Yoo GJ, Lee JU

  • KMID: 2254388
  • Korean J Nephrol.
  • 2002 Jul;21(4):525-530.
BACKGROUND: The present study was aimed at investigating whether there is a mechanism exerted by endogenous nitric oxide(NO) in the regulation of aquaporin(AQP) water channels in the kidney. METHODS: Male...
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Altered Renal Expression of Aquaporin-2 Water Channels in Two-Kidney, One Clip Hypertension in Rats

Lee SY

  • KMID: 2172442
  • Chonnam Med J.
  • 2000 Dec;36(4):337-342.
The present study was aimed at examining the regulation of aquaporin-2 (AQP2) water channels in the kidney in two-kidney, one clip (2K1C) hypertension. Rats were made 2K1C hypertensive for 6...
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A Minireview on Vasopressin-regulated Aquaporin-2 in Kidney Collecting Duct Cells

Park EJ, Kwon TH

The kidney collecting duct is an important renal tubular segment for the regulation of body water and salt homeostasis. Water reabsorption in the collecting duct cells is regulated by arginine...
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Altered Regulation of Aquaporin-2 Water Channels in the Kidney Following Acute Blood Volume Depletion in Rats

Li YS, Oh Y, Lee S, Lee JU

  • KMID: 2079270
  • Korean J Nephrol.
  • 2003 Jan;22(1):37-42.
BACKGROUND: The present study was aimed to examine the regulation of aquaporin (AQP)-2 water channels in the kidney following blood volume depletion. METHODS: Male Sprague-Dawley rats were acutely blood volume-depleted...
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Decreased expression of aquaporin-2 water channels in the kidney in rats treated with reserpine

Lee JU, Oh YW, Kim S

  • KMID: 2071570
  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):307-313.
Whether there exists a Sympathetic neural mechanism regulating the expression of aquaporin (AQP) water channels in the kidney was investigated. Male Sprague-Dawley rats were treated with reserpine (1 mg/kg, IP), and the expression...
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Decreased Expression of Aquaporin-2 Water Channels in the Kidney in Rats Treated with Chlorpropamide

Kim SW, Lee JU, Li YS, Oh YW, Kim NH, Choi KC

  • KMID: 2254431
  • Korean J Nephrol.
  • 2002 May;21(3):375-381.
BACKGROUND: Whether blood glucose levels may change the regulation of aquaporin(AQP) water channels in the kidney was investigated. METHODS: Male Sprague-Dawley rats were treated with chlorpropamide(40 mg/100 g body weight...
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Effect of Diet and Water Intake on Aquaporin 2 Function

Kim JM, Kim TH, Wang T

Appropriate control of diet and water intake is important for maintaining normal blood pressure, fluid and electrolyte homeostasis in the body. It is relatively understood that the amount of sodium...
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A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus

Kim K, Lee JH, Kim SC, Cha DR, Kang YS

Aldosterone-producing adrenal adenoma can induce various clinical manifestations as a result of chronic exposure to aldosterone. We report a rare case of a 37-year-old man who complained of general weakness...
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Sympathetic Regulation of Aquaporin Water Channels in Rat Kidney

Lee J, Yoo K, Oh Y, Lim DY

  • KMID: 2071594
  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):181-185.
Whether there exists a sympathetic neural regulation on the aquaporin (AQP) channels in the kidney was examined. Male Sprague-Dawley rats were used. They were renal nerve denervated by stripping the...
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New insights into the transcriptional regulation of aquaporin-2 and the treatment of X-linked hereditary nephrogenic diabetes insipidus

Jung HJ, Kwon TH

The kidney collecting duct (CD) is a tubular segment of the kidney where the osmolality and final flow rate of urine are established, enabling urine concentration and body water homeostasis....
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Effects of Bilateral Ureteral Obstruction on Renal Aquaporin Expression

Jeong SJ, Chung SY, Nam KI, Lee SW, Park SS, Ahn KY

  • KMID: 2254387
  • Korean J Nephrol.
  • 2002 Jul;21(4):516-524.
BACKGROUND: Obstruction of urinary tract is common cause of renal disfunction. Recent discovery of aquaporin water channels expressed in the kidney and various organs has faciliated our understanding of water...
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A Non-woven Path: Electrospun Poly(lactic acid) Scaffolds for Kidney Tissue Engineering

Burton TP, Callanan A

Chronic kidney disease is a major global health problem affecting millions of people; kidney tissue engineering provides an opportunity to better understand this disease, and has the capacity to provide...
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Enhanced Atrial Natriuretic Peptide and Nitric Oxide System Following the Treatment with Caffeine in Rats

Ha JH, Yeum CH, Kim SW, Kim NH, Choi KC, Lee JU

  • KMID: 2254463
  • Korean J Nephrol.
  • 2002 Jan;21(1):123-128.
PURPOSE: The present study was aimed to examine whether caffeine alters the local regulation of atrial natriuretic peptide(ANP) and nitric oxide(NO) systems in the kidney. METHODS: Male Sprague-Dawley rats were treated...
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Membrane Trafficking of Collecting Duct Water Channel Protein AQP2 Regulated by Akt/AS160

Jung HJ, Kwon TH

  • KMID: 2406195
  • Electrolyte Blood Press.
  • 2010 Dec;8(2):59-65.
Akt (protein kinase B (PKB)) is a serine/threonine kinase that acts in the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. The PI3K/Akt signaling pathway, triggered by growth factors and hormones including vasopressin,...
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Water and Sodium Regulation in Heart Failure

Bae EH, Ma SK

Heart failure is the pathophysiological state characterized by ventricular dysfunction and associated clinical symptoms. Decreased cardiac output or peripheral vascular resistance lead to arterial underfilling. That is an important signal...
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Two Novel Mutations in the Aquaporin 2 Gene in a Girl with Congenital Nephrogenic Diabetes Insipidus

Cheong HI, Cho SJ, Zheng SH, Cho HY, Ha IS, Choi Y

Congenital nephrogenic diabetes insipidus (CNDI) is a rare inherited disorder characterized by insensitivity of the kidney to the antidiuretic effect of vasopressin. There are three inheritance patterns of CNDI: the...
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Regulation of aquaporin-2 in the kidney : A molecular mechanism of body-water homeostasis

Kwon TH, Frokiaer J, Nielsen S

  • KMID: 2224302
  • Kidney Res Clin Pract.
  • 2013 Sep;32(3):96-102.
The kidneys play a key role in the homeostasis of body water and electrolyte balance. Aquaporin-2 (AQP2) is the vasopressin-regulated water-channel protein expressed at the connecting tubule and collecting duct,...
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Expression of Aquaporin-2 in the Inner Ear of Water-Deprived Guinea Pigs

Lee SS, Kim K, Kim JH, Cho HH, Jang CH, Cho YB

BACKGROUND AND OBJECTIVES: Although the role of aquaporin-2 (AQP2) in the kidney has been well defined, its role in the inner ear remains to be determined. The present study was...
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