- Anti-oxidative neuroprotection by estrogens in mouse cortical cultures
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Bae YH, Hwang JY, Kim YH, Koh JY
- KMID: 1128633
- J Korean Med Sci.
- 2000 Jun;15(3):327-336.
- doi: 10.3346/jkms.2000.15.3.327
Estrogen replacement therapy in postmenopausal women may reduce the risk of Alzheimer's disease, possibly by ameliorating neuronal degeneration. In the present study, we examined the neuroprotective spectrum of estrogen against... -
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- Effect of Antioxidants on the Incidence of 7, 12-dimethylbenzanthracene-induced Mammary Tumor in Rats
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Oh SH, Park YH
- KMID: 692973
- Yonsei Med J.
- 1984 Jun;25(1):39-45.
- doi: 10.3349/ymj.1984.25.1.39
The inhibitory effect of selenium, vitamin E, and BHA on DMBA-induced mammary tumorigenesis in rats was investigated. Dietary vitamin E (200 IU/Kg diet) alone could not reduce the tumor incidence... -
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- The effects of oxygen radicals on the activity of nitric oxide synthase and guanylate cyclase
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Kim SM, Byun JS, Jung YD, Kang IC, Choi SY, Lee KY
- KMID: 755012
- Exp Mol Med.
- 1998 Dec;30(4):221-226.
Reactive oxygen species such as superoxides, hydrogen peroxide (H2O2) and hydroxyl radicals have been suggested to be involved in the catalytic action of nitric oxide synthase (NOS) to produce NO... -
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- Inhibition of expression of P-selectin by antioxidant in cholesterol-fed rats
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Lee CS, Choi JM, Park DH, Kang DY, Register T, Adams MR
- KMID: 1062190
- J Korean Med Sci.
- 1999 Feb;14(1):8-14.
- doi: 10.3346/jkms.1999.14.1.8
Butylated hydroxytoluene (BHT) can inhibit experimental atherosclerosis in animals. Although the agent is an antioxidant, the exact mechanism of the reaction in atherosclerosis is still unknown. To investigate the effects... -
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- Doxorubicin-induced reactive oxygen species generation and intracellular Ca2+increase are reciprocally modulated in rat cardiomyocytes
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Kim SY, Kim SJ, Kim BJ, Rah SY, Chung SM, Im MJ, Kim UH
- KMID: 1098088
- Exp Mol Med.
- 2006 Oct;38(5):535-545.
Doxorubicin (DOX) is one of the most potent anticancer drugs and induces acute cardiac arrhythmias and chronic cumulative cardiomyopathy. Though DOX-induced cardiotoxicity is known to be caused mainly by ROS... -
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- Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats
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Dejanovic , Stevanovic I, Ninkovic M, Stojanovic I, Lavrnja I, Radicevic , Pavlovic M
- KMID: 2363335
- J Vet Sci.
- 2016 Mar;17(1):53-61.
- doi: 10.4142/jvs.2016.17.1.53
This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen... -
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- Gastroprotective Effects of PMK-S005 against Ethanol-Induced Acute Gastric Damage in Rats
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Choi YJ, Kim N, Lee JY, Nam RH, Seo JH, Lee S, Kim HJ, Choi YJ, Lee HS, Lee DH
- KMID: 2411960
- Gut Liver.
- 2016 May;10(3):348-355.
- doi: 10.5009/gnl14509
BACKGROUND/AIMS: This study aimed to examine the gastroprotective effects of PMK-S005, which is a synthetic S-allyl-L-cysteine (SAC; a sulfur-containing amino acid), against acute ethanol-induced gastric damage in rats. METHODS: Sprague-Dawley rats... -
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- Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice
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Yi J, Xia W, Wu J, Yuan L, Wu J, Tu D, Fang J, Tan Z
- KMID: 1737620
- J Vet Sci.
- 2014 Mar;15(1):141-148.
- doi: 10.4142/jvs.2014.15.1.141
Betulinic acid (BA), a pentacyclic lupane-type triterpene, has a wide range of bioactivities. The main objective of this work was to evaluate the hepatoprotective activity of BA and the potential... -
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- Assessment of Hemorheological Deformability of Human Red Cells Exposed to tert-Butyl Hydroperoxide, Verapamil and Ascorbate by Ektacytometer
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Kim DH, Kim YK, Won DI, Shin S, Suh JS
- KMID: 1781563
- Korean J Lab Med.
- 2008 Oct;28(5):325-331.
- doi: 10.3343/kjlm.2008.28.5.325
BACKGROUND: Normal erythrocyte is deformable and this facilitates blood flow in the capillaries. Oxidative stress reduces the deformability of erythrocytes, and influences on blood flow in microcirculation. The objective of... -
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- Effects of Chronic Aluminum Administration on Blood and Liver Iron-Related Parameters in Mice
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Turgut G, Kaptanoglu B, Turgut S, Enli Y, Genc O
- KMID: 1734104
- Yonsei Med J.
- 2004 Feb;45(1):135-139.
- doi: 10.3349/ymj.2004.45.1.135
In this study, the effects of chronically administered aluminum on iron metabolism-related parameters of liver and blood of mice were investigated. An additional purpose to determine how chronic aluminum administration... -
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- Adipogenic and Lipolytic Effects of Ascorbic Acid in Ovariectomized Rats
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Kim B, Choi KM, Yim HS, Park HT, Yim JH, Lee MG
- KMID: 2418853
- Yonsei Med J.
- 2018 Jan;59(1):85-91.
- doi: 10.3349/ymj.2018.59.1.85
PURPOSE: Ascorbic acid has been reported to have an adipogenic effect on 3T3-L1 preadipocytes, while evidence also suggests that ascorbic acid reduces body weight in humans. In this study, we... -
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- Effects of alpha-Tocopherol on Cadmium-Induced Toxicity in Rat Testis and Spermatogenesis
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Yang HS, Han DK, Kim JR, Sim JC
- KMID: 1778426
- J Korean Med Sci.
- 2006 Jun;21(3):445-451.
- doi: 10.3346/jkms.2006.21.3.445
Cadmium is known to exert toxic effects on multiple organs, including the testes. To determine if alpha-tocopherol, an antioxidant, could protect testicular tissues and spermatogenesis from the toxic effects of... -
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- Cytotoxicity of gamma-ray in rat immature hippocampal neurons
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Yang M, Song MS, Kim SH, Kim JC, Kim JS, Shin T, Moon C
- KMID: 1067390
- J Vet Sci.
- 2011 Sep;12(3):203-207.
- doi: 10.4142/jvs.2011.12.3.203
This in vitro study evaluated the detrimental effect of acute gamma (gamma)-irradiation on rat immature hippocampal neurons. Rat immature hippocampal neurons (0.5 day in vitro) were irradiated with 0~4 Gy... -
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- Tempol Attenuates Renal Fibrosis in Mice with Unilateral Ureteral Obstruction: The Role of PI3K-Akt-FoxO3a Signaling
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Yoon HE, Kim SJ, Kim SJ, Chung S, Shin SJ
- KMID: 1789980
- J Korean Med Sci.
- 2014 Feb;29(2):230-237.
- doi: 10.3346/jkms.2014.29.2.230
This study investigated whether tempol, an anti-oxidant, protects against renal injury by modulating phosphatidylinositol 3-kinase (PI3K)-Akt-Forkhead homeobox O (FoxO) signaling. Mice received unilateral ureteral obstruction (UUO) surgery with or without... -
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- Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA
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Chae MJ, Sung HY, Kim EH, Lee M, Kwak H, Chae CH, Kim S, Park WY
- KMID: 1122283
- Exp Mol Med.
- 2009 Nov;41(11):824-831.
- doi: 10.3858/emm.2009.41.11.088
Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-alpha mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE... -
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- Ionizing radiation induces blockade of c-Jun N-terminal kinasedependent cell death pathway in amanner correlated with p21Cip/WAF1 induction in primary cultured normal human fibroblasts
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Cho ES, Lee SB, Bae IH, Lee YS, Lee SJ, Um HD
- KMID: 1093463
- Exp Mol Med.
- 2005 Aug;37(4):282-289.
During radiotherapy of cancer, neighboring normal cells may receive sub-lethal doses of radiation. To investigate whether such low levels of radiation modulate normal cell responses to death stimuli, primary cultured... -
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- Ascorbic Acid Alleviates Pancreatic Damage Induced by Dibutyltin Dichloride (DBTC) in Rats
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Lu XL, Song YH, Fu YB, Si JM, Qian KD
- KMID: 1786220
- Yonsei Med J.
- 2007 Dec;48(6):1028-1034.
- doi: 10.3349/ymj.2007.48.6.1028
PURPOSE: Because previous studies have reported depleted antioxidant capacity in patients with chronic pancreatitis (CP), prevention of free radical production has gained importance in antifibrotic treatment strategies for CP.... -
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- Intake of Dietary Fat and Vitamin in Relation to Breast Cancer Risk in Korean Women: A Case-Control Study
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Do MH, Lee SS, Jung PJ, Lee MH
- KMID: 648905
- J Korean Med Sci.
- 2003 Aug;18(4):534-540.
- doi: 10.3346/jkms.2003.18.4.534
To investigate association between breast cancer risk and nutrients intake in Korean women, a case-control study was carried out, at Seoul, Korea. Incident cases (n=224) were identified through the cancer... -
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