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A Portulaca oleracea L. extract promotes insulin secretion via a K⁺(ATP) channel dependent pathway in INS-1 pancreatic β-cells

Park JE, Han JS

BACKGROUND/OBJECTIVE: This study was designed to investigate how a Portulaca oleracea L. extract (POE) stimulates insulin secretion in INS-1 pancreatic β-cells. MATERIALS/METHOD: INS-1 pancreatic β-cells were incubated in the presence of...
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Pear pomace water extract inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes

Rhyu J, Kim MS, You MK, Bang MA, Kim HA

  • KMID: 2313708
  • Nutr Res Pract.
  • 2014 Feb;8(1):33-39.
Obesity occurs when a person's calorie intake exceeds the amount of energy burns, which may lead to pathologic growth of adipocytes and the accumulation of fat in the tissues. In...
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Neuroendocrine Differentiation in Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

Chang Y, Kim SY, Choi YJ, So KS, Rho JK, Kim WS, Lee JC, Chung JH, Choi CM

  • KMID: 2320446
  • Tuberc Respir Dis.
  • 2013 Sep;75(3):95-103.
BACKGROUND: Small cell lung cancer (SCLC) transformation during epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment in lung cancer has been suggested as one of possible resistance mechanisms. METHODS: We...
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Inhibitory Effect of Vitamin U (S-Methylmethionine Sulfonium Chloride) on Differentiation in 3T3-L1 Pre-adipocyte Cell Lines

Lee NY, Park KY, Min HJ, Song KY, Lim YY, Park J, Kim BJ, Kim MN

BACKGROUND: S-methylmethionine sulfonium chloride was originally called vitamin U because of its inhibition of ulceration in the digestive system. Vitamin U is ubiquitously expressed in the tissues of flowering plants,...
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Involvement of Crosstalk Between cAMP and cGMP in Synaptic Plasticity in the Substantia Gelatinosa Neurons

Kim TH, Chung G, Park SB, Chey WY, Jung SJ, Kim JS, Oh SB

  • KMID: 2170737
  • Int J Oral Biol.
  • 2011 Jun;36(2):83-89.
Substantia gelatinosa (SG) neurons receive synaptic inputs from primary afferent Adelta- and C-fibers, where nociceptive information is integrated and modulated by numerous neurotransmitters or neuromodulators. A number of studies were...
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Effect of xanthohumol on melanogenesis in B16 melanoma cells

Koo JH, Kim HT, Yoon HY, Kwon KB, Choi IW, Jung SH, Kim HU, Park BH, Park JW

Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis in B16 melanoma cells, with little cytotoxicity at the effective concentrations. Decreased melanin...
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Characterization and Functional Analysis of Obox4 during Oocyte Maturation by RNA Interference

Lee HS, Lee KA

  • KMID: 2288251
  • Korean J Reprod Med.
  • 2007 Dec;34(4):293-303.
OBJECTIVE: Previously, we identified differentially expressed genes between GV and MII stage mouse oocytes using ACP technology.1 When we study one of GV selective genes, Obox family, we found Obox4...
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The Effect of cAMP-Elevating Agents on High Glucose-Induced Apoptosis of Isolated Islets of Rat Pancreas

Koh GP, Suh KS, Chon S, Oh SJ, Woo JT, Kim SW, Kim JW, Kim YS, Kwon SH

  • KMID: 2008177
  • J Korean Diabetes Assoc.
  • 2004 Dec;28(6):490-500.
BACKGROUND: High glucose-induced apoptosis has been implicated in the loss of beta-cells of the pancreatic islets in animal models of type 2 diabetes. GLP-1 has been shown to reduce apoptosis...
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A novel Na+-dependent transporter and NHE3 mediate H+ efflux in the luminal membrane of the pancreatic duct: regulation by cAMP

Lee MG, Ahn W, Choi JY, Muallem S, Kim KH

No abstract available.
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Involvement of Spontaneously Formed Cyclic Nucleotides in Cat Gastric Muscle Relaxation

Sim SS, Baek HJ, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS

  • KMID: 2285221
  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):275-282.
Muscle strips and muscle cells from cat stomach were used to investigate whether spontaneously formed cyclic nucleotides were involved in the inhibition of gastric smooth muscle contraction. A phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (IBMX), increased the...
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The Effect of Local Delivery of IBMX on the Neointimal Proliferation in Rat Carotid Balloon Injury Model

Lee BK, Yoon J, Lee HH, Kim JY, Ko JY, Lee SH, Yoo BS, Hwang SO, Choe KH

BACKGROUND: Hyperplastic neointima is one of the major mechanisms of restenosis following balloon angioplasty in selected patients with symptomatic angina pectoris. Elevation of cellular cyclic nucleotide levels such as cAMP...
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Hydroxyl radical-mediated commitment of HL-60 cells to differentiation: Modulation of differentiation process by phosphodiesterase inhibitors

Cho JY, Ahn WS, Cha SH, Lee KH, Kim WI, Chung MH

  • KMID: 1849845
  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):369-376.
Ms report shows that hydroxyl radical, generated by a Fenton reaction involving adenosine 5'-diphosphate/Fe2+ complex (5-15 micrometer) and H2O2 (2 micrometer), induced differentiation of HL-60 cells in a dose- and time-dependent manner. This...
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Increase of L-type calcium current by cGMP-dependent protein kinase regulates in rabbit ventricular myocytes

Han J, Kim N, Kim E, Ho W, Earm YE, Kim H

  • KMID: 2071832
  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):733-742.
BACKGROUND: We have previously reported that not only cGMP but also 8-Br-cGMP or 8-pCPT-cGMP, specific and potent stimulators of cGMP-dependent protein kinase (cGMP-PK), increased basal L-type calcium current (ICa) in rabbit ventricular myocytes....
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Effect and Mechanism of Growth Factors and Their Interactions on the Expression of c-fos and c-myc Proto-oncogenes in Cultured Normal Rat Thyroid Cell Line (FRTL-5)

Yoo HY, Oh SK

  • KMID: 2206227
  • J Korean Surg Soc.
  • 1997 Jun;52(6):771-784.
Oncogenes are known to be involved in normal cellular growth and proliferation as well as in carcinogenesis. It is reported that stimulation of quiescent cells with growth factors makes the...
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ANP inhibits surfactant secretion from isoproterenol stimulated alveolar type II cells

Lee YM

  • KMID: 2285159
  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):65-70.
In order to investigate the effect of ANP on surfactant secretion from alveolar type II cell(AT II cell) during circulatory derangement in adult respiratory distress syndrome (ARDS), the secretion of surfactant from AT...
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Effects of cyclic-GMP on hyperpolarization-activated inward current (I|f) in sino-atrial node cells of rabbit

Shin Y, Ho WK, Earm YE

  • KMID: 2285191
  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):731-739.
The aim of present study is to investigate the effects of cGMP on hyperpolarization activated inward current (If), pacemaker current of the heart, in rabbit sino-atrial node cells using the whole-cell patch clamp...
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Effects of Volatile Anesthetics on Aortic Contractile Responses in Endotoxemic Rats

Kang SH, Moon CW, Lim DG, Kim IK, Park JW

BACKGROUND: Endotoxins play important roles in the pathophysiologic alterations associated with sepsis so we examined the effects of volatile anesthetics on vascular smooth muscle contractile function in LPS-treated rat aorta. METHODS:...
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Effects of supernatants of cultured keratinocytes on melanocyte proliforation and melanization

Suh WS, Lee MH, Park JK, Haw CR

  • KMID: 1692685
  • Korean J Dermatol.
  • 1991 Apr;29(2):139-150.
To evaluate the effects of kerationocytes on the growth of melanocytes, keratinocyte conditioned media (K-CM) with different molecular weight obtained by dialysis were added to melanocyte growth medium (M-GM). In...
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