Korean J Hepatol.  2004 Sep;10(3):223-227.

Mucinous Cholangiocarcinoma associated with Clonorchis sinensis Infestation: A Case Report

• Shim HS
• Lim BJ
• Kim MJ
• Lee WJ
• Park C
• Park YN

Abstract

Mucinous cholangiocarcinoma, characterized by large quantities of mucin production, is a rare subtype of peripheral cholangiocarcinoma and usually shows rapid progression and a fatal outcome. We report here a case of mucinous cholangiocarcinoma in a 69 year-old man, who was infected with Clonorchis sinensis. Histologically, the tumor was an adenocarcinoma with extensive intracellular and extracellular mucin production, up to 70% of the tumor mass and there was frequent lymphovascular invasion of the tumor cells. The liver adjacent to the mass contained eggs of Clonorchis sinensis in the bile duct lumen and showed ductal epithelial hyperplasia, mucinous metaplasia and adenomatous proliferation of intramural glands. The patient was treated with a right hepatectomy. Four months after the surgery, the tumor recurred in the soft tissue of the right flank.

Keyword

Cholangiocarcinoma; Mucin; Clonorchis sinensis

MeSH Terms

Aged
Bile Duct Neoplasms/*complications/secretion
*Bile Ducts, Intrahepatic
Cholangiocarcinoma/*complications/secretion
Clonorchiasis/*complications
English Abstract
Humans
Male
Mucins/secretion