Yonsei Med J.  2000 Jun;41(3):398-400. 10.3349/ymj.2000.41.3.398.

Assignments of the tyrosinase related protein-1 and -2 genes to human chromosome bands 9p23 and 13q32.1 by in situ hybridization

Affiliations
  • 1Institute for Medical Sciences, College of Natural Sciences, Ajou University, Suwon, Korea. wkim@ madang.ajou.ac.kr
  • 2Department of Dermatology, School of Medicine, Ajou University, Suwon, Korea.
  • 3Department of Biological Sciences, College of Natural Sciences, Ajou University, Suwon, Korea.

Abstract

To determine the precise chromosomal localization of tyrosine related protein-1 and -2 (TRP-1 and TRP-2) genes by fluorescence in situ hybridization, we used DNAs isolated from human bacterial artificial chromosome clones. They contain genomic sequences with approximately 120 kb inserts for TRP-1 and TRP-2. The TRP-1 and TRP-2 genes were assigned to human chromosome bands 9p23 and 13q32.1, respectively. These results confirmed the previously mapped location for the TRP-1 gene and more precisely located the TRP-2 gene, which had previously been mapped to chromosome 13q31-q32.

Keyword

Tyrosine related proteins; bacterial artificial chromosome library; fluorescence in situ hybridization

MeSH Terms

Chromosomes, Human, Pair 13/genetics*
Chromosomes, Human, Pair 9/genetics*
Gene Library
Human
In Situ Hybridization, Fluorescence
Intramolecular Oxidoreductases/genetics*
Proteins/genetics*
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