Yonsei Med J.  1996 Feb;37(1):52-58. 10.3349/ymj.1996.37.1.52.

Decreased CD5+ B cells during the acute phase of Kawasaki disease

• Kim HS
• Noh GW
• Kim DS
• Lee KY
• Lee HS
• Lee HK
• Lee SI

• KMID: 699873
• DOI: http://doi.org/10.3349/ymj.1996.37.1.52

Abstract

We investigated the changes of CD5+ B cells in the peripheral blood of 20 Kawasaki disease (KD) patients. The percentage of CD5+ B cells in the total lymphocytes and in the total B cells significantly decreased during the acute phase of KD(p< 0.01), compared to that in the age-matched normal control subjects. After intravenous immunoglobulin(IVIG) treatment, the percentage of CD5+ B cells increased, but was still lower than that in the normal controls(p< 0.01). During the convalescent phase of the disease, the percentage of CD5+ B cells was restored to the normal levels. The levels of CD5+ B cell percentage in the total B cells of the patients with acute febrile disease showed similar levels to age-matched normal controls. The decreased CD5+ B cells in the patients with KD provides an additional abnormal immunological finding during the acute phase of the disease.

Keyword

CD5+B cell; Kawasaki disease; IVIG

MeSH Terms

Acute Disease
Antigens, CD5/*analysis
B-Lymphocytes/*immunology
Child
Child Preschool
Female
Human
Infant
Male
Mucocutaneous Lymph Node Syndrome/*immunology/physiopathology
Reference Values