Yonsei Med J.
1988 Mar;29(1):62-65. 10.3349/ymj.1988.29.1.62.
Sulpiride in Meige's Syndrome: Possible Role of Glutamate
- Affiliations
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- 1Department of Neurology, Yonsei University College of Medicine, Korea.
- 2Department of Internal Medicine, College of Medicine, Ewha University, Seoul, Korea.
- KMID: 693112
- DOI: http://doi.org/10.3349/ymj.1988.29.1.62
Abstract
- Sulpiride, a selective antagonist for adenylate cyclase-independent dopamine receptors, was administrated to 25 patients with blepharospasm and oromandibular dystonia(Meige's syndrome). Of the 25, 7 patients (28%) exhibited marked and lasting improvement with sulpiride and 12 patients (48%) showed mild or transient improvement. This favorable therapeutic response to sulpiride suggests that striatal glutamate underactivity may play a role in the pathophysiology of Meige's syndrome as a primary or secondary defect.
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