- Enzymes involved in folate metabolism and its implication for cancer treatment
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Kim SE
- KMID: 2471876
- Nutr Res Pract.
- 2020 Apr;14(2):95-101.
- doi: 10.4162/nrp.2020.14.2.95
BACKGROUND/OBJECTIVES: Folate plays a critical role in DNA synthesis and methylation. Intracellular folate homeostasis is maintained by the enzymes folylpolyglutamate synthase (FPGS) and γ-glutamyl hydrolase (GGH). FPGS adds glutamate residues... -
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- Connecting the dots between SHP2 and glutamate receptors
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Ryu HH, Kim SY, Lee YS
- KMID: 2471034
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):129-135.
- doi: 10.4196/kjpp.2020.24.2.129
SHP2 is an unusual protein phosphatase that functions as an activator for several signaling pathways, including the RAS pathway, while most other phosphatases suppress their downstream signaling cascades. The physiological... -
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- Analysis of interaction between intracellular spermine and transient receptor potential canonical 4 channel: multiple candidate sites of negatively charged amino acids for the inward rectification of transient receptor potential canonical 4
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Kim J, Moon SH, Kim T, Ko J, Jeon YK, Shin YC, Jeon JH, So I
- KMID: 2466574
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):101-110.
- doi: 10.4196/kjpp.2020.24.1.101
Transient receptor potential canonical 4 (TRPC4) channel is a nonselective calcium-permeable cation channels. In intestinal smooth muscle cells, TRPC4 currents contribute more than 80% to muscarinic cationic current (mIcat). With... -
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- Meta-analysis on the Efficacy of Glutamate Receptor Antagonists for Acute Migraine Treatment
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Kim S, Baek IH
- KMID: 2470462
- Korean J Clin Pharm.
- 2019 Dec;29(4):247-253.
- doi: 10.24304/kjcp.2019.29.4.247
BACKGROUND: Glutamate is implicated in the pathophysiology of migraine, a common neurological disorder. Therefore, glutamate receptor antagonists (GluRAs) have been suggested as a novel migraine treatment that are able to... -
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- Optimization of Growth Medium and Fermentation Conditions for the Production of Laccase3 from Cryphonectria parasitica Using Recombinant Saccharomyces cerevisiae
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Jeong YS, So KK, Lee JH, Kim JM, Chun GT, Chun J, Kim DH
- KMID: 2470184
- Mycobiology.
- 2019 Dec;47(4):512-520.
- doi: 10.1080/12298093.2019.1661566
Statistical experimental methods were used to optimize the medium for mass production of a novel laccase3 (Lac3) by recombinant Saccharomyces cerevisiae TYEGLAC3-1. The basic medium was composed of glucose, casamino... -
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- Identification of proteins differentially expressed by glutamate treatment in cerebral cortex of neonatal rats
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Kang JB, Park DJ, Koh PO
- KMID: 2470014
- Lab Anim Res.
- 2019 Dec;35(4):172-179.
- doi: 10.1186/s42826-019-0026-9
Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal cerebral... -
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- Screening Moringa species focused on development of locally available sustainable nutritional supplements
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Kim YJ, Kim HS
- KMID: 2464132
- Nutr Res Pract.
- 2019 Dec;13(6):529-534.
- doi: 10.4162/nrp.2019.13.6.529
BACKGROUND/OBJECTIVES: The leaves of Moringa oleifera (MO) and Moringa stenopetala (MS) commonly grown in Ethiopia possess potential nutritional and medicinal value. The aim of this study was to evaluate the... -
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- Evaluation of Transcranial Magnetic Stimulation Efficiency in Major Depressive Disorder Patients: A Magnetic Resonance Spectroscopy Study
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Erbay MF, Zayman EP, Erbay LG, Ãœnal S
- KMID: 2462773
- Psychiatry Investig.
- 2019 Oct;16(10):745-750.
- doi: 10.30773/pi.2019.07.17.3
OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD). This study evaluated the antidepressant effect of rTMS and examined how it affected N-asetyl aspartate... -
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- Metabolomics approach to serum biomarker for laxative effects of red Liriope platyphylla in loperamide-induced constipation of SD rats
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Kim JE, Lee YJ, Ryu SH, Park JW, Kang MJ, Choi HJ, Bae SJ, Choi Y, Kang HG, Kim KB, Kim S, Lim Y, Hwang DY
- KMID: 2470108
- Lab Anim Res.
- 2019 Aug;35(2):52-60.
- doi: 10.1186/s42826-019-0009-x
Red Liriope platyphylla (RLP) is a known herbal medicine used in the treatment of some chronic diseases including constipation, neurodegenerative disorders, diabetes and obesity. To determine and characterize putative biomarkers... -
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- Memantine Attenuates Salicylate-induced Tinnitus Possibly by Reducing NR2B Expression in Auditory Cortex of Rat
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Jang CH, Lee S, Park IY, Song A, Moon C, Cho GW
- KMID: 2458547
- Exp Neurobiol.
- 2019 Aug;28(4):495-503.
- doi: 10.5607/en.2019.28.4.495
Memantine, a noncompetitive antagonist of the N-methyl-d-aspartate (NMDA) receptor, suppresses the release of excessive levels of glutamate that may induce neuronal excitation. Here we investigated the effects of memantine on... -
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- Riluzole Selective Antioxidant Effects in Cell Models Expressing Amyotrophic Lateral Sclerosis Endophenotypes
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Sala G, Arosio A, Conti E, Beretta S, Lunetta C, Riva N, Ferrarese , Tremolizzo L
- KMID: 2457408
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):438-442.
- doi: 10.9758/cpn.2019.17.3.438
OBJECTIVE: Until recently, riluzole was the only drug licensed for amyotrophic lateral sclerosis (ALS). In spite of its efficacy, the mechanism of action remains elusive, and both blocking of glutamate... -
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- The Effect of Oral Administration of Black Sticky Rice with Giant Embryo on Brain GABA Concentrations
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Jung WY, Kim SG, Kim HK, Huh SY, Kim DW, Yoon DU, Yang CH, Kim HY, Jang EY
- KMID: 2456172
- Psychiatry Investig.
- 2019 Aug;16(8):615-620.
- doi: 10.30773/pi.2019.05.13.2
OBJECTIVE: Black sticky rice with giant embryo (BSRGE) contains high GABA content and affects alcohol-related indices among social drinkers, and alcohol intake and anxiety-related behavior of mice. However, it is... -
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- Therapeutic Effects of Amino Acids in Liver Diseases: Current Studies and Future Perspectives
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Lee DY, Kim EH
- KMID: 2454667
- J Cancer Prev.
- 2019 Jun;24(2):72-78.
- doi: 10.15430/JCP.2019.24.2.72
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver and the third most common cause of cancer-related death worldwide. HCC is caused by infection of hepatitis... -
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- Polymorphisms of Ionotropic Glutamate Receptor-Related Genes and the Risk of Autism Spectrum Disorder in a Chinese Population
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Xie X, Hou F, Li L, Chen Y, Liu L, Luo X, Gu H, Li X, Zhang J, Gong J, Song R
- KMID: 2449910
- Psychiatry Investig.
- 2019 May;16(5):379-385.
- doi: 10.30773/pi.2019.02.26.3
OBJECTIVE: To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population. METHODS: We performed spatio-temporal expression analysis of GRIK2 and NLGN1 in the developing prefrontal... -
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- Analysis of 12 Chinese Patients with Proline-to-Leucine Mutation at Codon 102-Associated Gerstmann-Sträussler-Scheinker Disease
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Wang J, Xiao K, Zhou W, Shi Q, Dong XP
- KMID: 2467732
- J Clin Neurol.
- 2019 Apr;15(2):184-190.
- doi: 10.3988/jcn.2019.15.2.184
BACKGROUND AND PURPOSE: Gerstmann-Sträussler-Scheinker disease (GSS) with a proline-to-leucine mutation at codon 102 (P102L) in the PRNP gene is the most frequently reported GSS subtype worldwide. This study aimed to... -
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- The Clinical Value of PELP1 for Breast Cancer: A Comparison with Multiple Cancers and Analysis in Breast Cancer Subtypes
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Wang X, Tsang JY, Lee MA, Ni YB, Tong JH, Chan SK, Cheung SY, To KF, Tse GM
- KMID: 2464416
- Cancer Res Treat.
- 2019 Apr;51(2):706-717.
- doi: 10.4143/crt.2018.316
PURPOSE: Proline, glutamic acid, and leucine-rich protein 1 (PELP1), a novel nuclear receptor (NR) co-regulator, is highly expressed in breast cancer. We investigated its expression in breast cancer subtypes, in... -
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- Glutamine Supplementation Ameliorates Chronic Stress-induced Reductions in Glutamate and Glutamine Transporters in the Mouse Prefrontal Cortex
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Baek JH, Vignesh A, Son H, Lee DH, Roh GS, Kang SS, Cho GJ, Choi WS, Kim HJ
- KMID: 2450218
- Exp Neurobiol.
- 2019 Apr;28(2):270-278.
- doi: 10.5607/en.2019.28.2.270
Chronic immobilization stress (CIS) induces low levels of glutamate (Glu) and glutamine (Gln) and hypoactive glutamatergic signaling in the mouse prefrontal cortex (PFC), which is closely related to the Glu-Gln... -
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- Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRAC(swell)) in the Brain
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Han YE, Kwon J, Won J, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ
- KMID: 2450213
- Exp Neurobiol.
- 2019 Apr;28(2):183-215.
- doi: 10.5607/en.2019.28.2.183
In the brain, a reduction in extracellular osmolality causes water-influx and swelling, which subsequently triggers Clâ»- and osmolytes-efflux via volume-regulated anion channel (VRAC). Although LRRC8 family has been recently proposed... -
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- Dexmedetomidine and propofol sedation requirements in an autistic rat model
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Elmorsy SA, Soliman GF, Rashed LA, Elgendy H
- KMID: 2447512
- Korean J Anesthesiol.
- 2019 Apr;72(2):169-177.
- doi: 10.4097/kja.d.18.00005
BACKGROUND: Autism is a challenging neurodevelopmental disorder. Previous clinical observations have suggested altered sedation requirements for children with autism. Our study aimed to test this observation experimentally in an animal... -
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- Antioxidant effects of kimchi supplemented with black raspberry during fermentation protect against liver cirrhosis-induced oxidative stress in rats
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Ryu EH, Yang JS, Lee MJ, Kim SH, Seo HY, Jung JH
- KMID: 2442365
- Nutr Res Pract.
- 2019 Apr;13(2):87-94.
- doi: 10.4162/nrp.2019.13.2.87
BACKGROUND/OBJECTIVES: Oxidative stress is a major effector of various diseases; accordingly, antioxidants are frequently ingested in order to prevent or alleviate disease symptoms. Kimchi contains various natural antioxidants, and it... -
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