Infect Chemother.  2025 Mar;57(1):168-171. 10.3947/ic.2024.0131.

Cytomegalovirus Retinitis in a Hematopoietic Stem Cell Transplant Recipient During Maribavir Pre-emptive Therapy

Affiliations
  • 1Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • 2Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • 3Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Abstract

We report a case of cytomegalovirus retinitis in a hematopoietic stem cell transplant recipient during valganciclovir pre-emptive therapy followed by maribavir. Analysis of UL97 mutation revealed a C480F substitution associated with high maribavir resistance and low ganciclovir resistance.

Keyword

Cytomegalovirus; Hematopoietic stem cell transplant; Breakthrough infection; Maribavir; Antiviral resistance
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