Korean J Ophthalmol.
2025 Apr;39(2):134-144. 10.3341/kjo.2024.0094.
Long-term Outcome and Related Risk Factors in Implantable Collamer Lens Implantation of High Myopia
- Affiliations
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- 1Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea
- 2Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea
- 3Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
- KMID: 2566408
- DOI: http://doi.org/10.3341/kjo.2024.0094
Abstract
- Purpose
To investigate the long-term efficacy and safety of posterior chamber implantable collamer lens (ICL) implantation in high myopia, and the risk factors associated with endothelial cell loss (ECL) or cataract development.
Methods
Medical records of 66 eyes of 37 patients who underwent ICL implantation for high myopia were retrospectively analyzed with a mean follow-up of 12 years. Changes in best-corrected visual acuity (logarithm of the minimum angle of resolution), intraocular pressure (IOP), refractive power, and endothelial cell density over time were analyzed with the incidence of cataract and IOP elevation. Risk factors were analyzed for their association with ECL or cataract development.
Results
At 10 years after surgery, the mean uncorrected visual acuity was 0.06 and the spherical equivalent was –0.90 diopters. By year 10, cataract was present in 13 of 66 eyes (19.7%), whereas glaucoma was found in 1 of 66 eyes (1.5%). Although IOP continuously elevated over time (p < 0.05), it remained within normal limits. The cataract group had a lower vault of ICL and a higher mean age at surgery (p < 0.05). Endothelial cell density remained above 2,000/mm2 in 98.5% of cases, with an average annualized rate of decline of 1.13%. The high annualized rate group (>1.13% loss per year) had a lower mean age than in the low annualized rate group (<1.13% loss per year, p < 0.05).
Conclusions
This indicates that ICL implantation is effective for high myopia, and its main complication is cataract and ECL. It also suggests that ECL and cataract should be regularly monitored although ECL looks stable in long-term follow-up. Age may affect both ECL and cataract, while low-vault ICL may affect cataract.
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