Korean J Med.  2025 Apr;100(2):45-53. 10.3904/kjm.2025.100.2.45.

Latest Insights into Long COVID Diagnosis and Treatment

Affiliations
  • 1Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea
  • 2Division of Infectious Diseases, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
  • 3Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
  • 4Health, Welfare and Gender Equality Team, Social and Cultural Research Office, National Assembly Research Service, Seoul, Korea
  • 5Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
  • 6Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea
  • 7Department of Psychiatry, National Medical Center, Seoul, Korea
  • 8Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea
  • 9Division of Infectious Diseases, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea
  • 10Division of Cardiology, Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Seoul, Korea
  • 11Department of Neurology, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea
  • 12Division of Infectious Diseases, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea

Abstract

Long coronavirus disease (COVID) is a condition in which coronavirus disease 2019 (COVID-19) symptoms persist for over 3 months, and currently poses a global public health challenge. Due to varying manifestations and lack of standardized definitions, diagnostic methods, and treatments, comprehensive clinical guidelines are required. This review article, summarizing research and expert consensus up to June 2023, provides recommendations for diagnosis and long-term management of long COVID symptoms. It emphasizes thorough patient evaluation, including medical history, physical examinations, and tests, and advocates vaccination and antiviral treatments to reduce risk. Guidelines for long COVID will be updated as new knowledge emerges.

Keyword

Long COVID; Postacute sequelae of COVID; Diagnosis; Treatment; 만성 코로나19증후군; 코로나바이러스 질환의 급성 후유증; 진단; 치료
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