Korean J Pancreas Biliary Tract.  2025 Jan;30(1):31-35. 10.15279/kpba.2025.30.1.31.

Asparaginase-Associated Pancreatitis and Pancreatic Pseudocyst Managed with Endoscopic Cystogastrostomy in Adult Acute Lymphoblastic Leukemia

• Park G
• Kim ES
• Choi HS
• Keum B
• Jeen YT
• Chun HJ
• Lee HS
• Lee JM

• KMID: 2564038
• DOI: http://doi.org/10.15279/kpba.2025.30.1.31

Abstract

Anticancer treatment for acute lymphocytic leukemia is based on drugs such as methotrexate, 6-mercaptopurine, vincristine, and asparaginase. Asparaginase-related pancreatitis is known to have an incidence of up to 18%, and is a major cause of discontinuation of anticancer treatment for leukemia due to acute onset and chronic complications. There were various cases of treatment of peripancreatic fluid retention caused by anticancer drugs in leukemia patients. Use of lumen-apposing metal stents (LAMS) for walled-off necrosis (WON) drainage has recently increased. The electrocautery-enhanced delivery system allowed simpler and faster stent placement, streamlining the overall procedure and potentially reducing procedure time. Therefore, favorable outcomes have been reported with the use of LAMS for endoscopic drainage of various conditions. In this paper, we discuss a case in which hot-system LAMS was performed to treat L-asparaginase-induced acute pancreatitis and pancreatic pseudocyst in an adult patient with acute lymphoblastic leukemia.

Keyword

Stents; Pancreatitis; Asparaginase; Lymphoid leukemia; Pancreatic pseudocyst; 스텐트; 췌장염; 아스파라기나제; 림프구성 백혈병; 췌장 가성낭종