Korean J Dent Mater.  2023 Dec;50(4):205-216. 10.14815/kjdm.2023.50.4.205.

Effect of ibandronate treatment on Ti mesh modified by anodic oxidation and cyclic pre-calcification

• Byeon SM
• Kim KS
• Shin JW
• Oh CC
• Kim TH
• Jang YS
• Lee MH
• Bae TS
• Ahn SG

• KMID: 2550708
• DOI: http://doi.org/10.14815/kjdm.2023.50.4.205

Abstract

Titanium mesh is commonly employed to reinforce missing alveolar ridges and promote bone regeneration around implants. However, the bioinertness of titanium mesh must be improved. This study evaluated the effect of improving bioactivity and bone regeneration by loading a calcium phosphate coating layer and ibandronate onto a titanium mesh with a nanotube-structured TiO₂ layer. The surface treatment of titanium mesh was divided into four groups: (1) No treatment; (2) Formation of nanotube TiO₂ layer; (3) Cyclic calcification pretreatment (calcium phosphate coating layer) after the formation of a nanotube TiO₂ layer; (4) Calcium phosphate coating and ibandronate loading after the formation of a nanotube TiO₂ layer. The release amount of ibandronate was analyzed using a UV spectrophotometer, and bioactivity was assessed through XRD, EDS, and HR FE-SEM to observe changes in the surface layer after immersion in simulated body fluid (SBF). Hydroxyapatite was uniformly distributed on the surface of the (4) group immersed in SBF, and calcium and phosphorus content also increased over time. This result supported that bioactivity was improved. The continuous release of ibandronate over 10 days may contribute to realizing a mechanism that improves osseointegration between bone and titanium mesh. These results showed that bioactivity was improved as calcium phosphate precipitated on the surface of the nanostructured titanium mesh. Additionally, it is believed that combined ibandronate can effectively increase the stability of titanium mesh and promote bone regeneration.

Keyword

Ti mesh; Bioactivity; Ibandronate; Anodic oxidation; Cyclic pre-calcification