Korean J Dermatol.  2023 Jun;61(5):308-312.

A Case of Acantholytic Squamous Cell Carcinoma on a Male Areola: An Uncommon Histologic Variant at a Rare Location

  • 1Departments of Dermatology , Inje University Sanggye Paik Hospital, Seoul, Korea
  • 2Departments of Surgery, Inje University Sanggye Paik Hospital, Seoul, Korea


The areola is a rare location for squamous cell carcinoma (SCC) because sunlight exposure, the main risk factor for SCC, is unusual on it. Acantholytic SCC (ASCC) is a rare histologic variant of SCC, characterized by pseudoglandular appearance with acantholytic tumor cells. A 59-year-old male presented a painful erythematous papule on his right areola. He had a history of psoralen ultraviolet A phototherapy for psoriasis in his 20s. Biopsy revealed an epithelial tumor and pseudoglandular structures with acantholytic tumor cells. In immunohistochemistry, cytokeratin 5/6, epithelial membrane antigen, and p63 were positive, while cytokeratin 7, carcinoembryonic antigen, S-100, and estrogen and progesterone receptors were negative. Periodic acid-Schiff stain was negative. Ki-67 labeling index was 79.7%. The final diagnosis was ASCC of the areola. After wide local excision, recurrence have not been reported. Here, we report a case of ASCC on the areola, focusing on its rare histologic variant and uncommon location.


Acantholytic squamous cell carcinoma; Areola; Psoralen ultraviolet A phototherapy; Squamous cell carcinoma
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