Kidney Res Clin Pract.
2023 Mar;42(2):166-173. 10.23876/j.krcp.22.083.
Histologic evaluation of activity and chronicity of lupus nephritis and its clinical significance
- Affiliations
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- 1Department of Pathology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
- 2Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA
- 3Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea
- KMID: 2543771
- DOI: http://doi.org/10.23876/j.krcp.22.083
Abstract
- The National Institutes of Health (NIH) lupus nephritis activity and chronicity indices, which comprise six activity scores and four chronicity scores, have a long development history. The 2018 revised International Society of Nephrology/Renal Pathology Society classification for lupus nephritis adopted the most recent NIH indices to replace subclasses A, C, and A/C. Although an evidence-based approach should further evaluate the clinical significance of the modified NIH indices, recent validation studies demonstrated that the modified chronicity indices have a strong correlation with kidney outcome of lupus nephritis.
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