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Clinical and Genetic Risk Factors Associated With the Presence of Lupus Nephritis

Shin JM, Kim D, Kwon YC, Ahn GY, Lee J, Park Y, Lee YK, Lee TH, Park DJ, Song YJ, Ha E, Kim K, Bang SY, Choi CB, Lee HS, Bae SC

Objective To elucidate whether clinical features and the weighted genetic risk score (wGRS) were associated with the presence of lupus nephritis (LN). Methods We retrospectively divided patients with systemic lupus...
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Worse Renal Presentation and Prognosis in Initial-Onset Lupus Nephritis than Early-Onset Lupus Nephritis

Kwon OC, Park JH, Lee SW, Song JJ, Park YB, Park MC

Purpose: To compare the clinical characteristics and renal outcomes between patients who initially had lupus nephritis (LN) at the onset of systemic lupus erythematosus (SLE) (initial-onset LN) and those who...
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Antepartum Diagnosis and Treatment of Diffuse Alveolar Hemorrhage in a Pregnant Woman with Systemic Lupus Erythematosus

Kim HS, Jeon HS, Han SJ, Kim JH, Chang JH, Oh YK, Shin K, Kim BJ, Lee SM

Diffuse alveolar hemorrhage (DAH) is a rare and life-threatening complication of systemic lupus erythematosus. Differential diagnosis and successful management of DAH can be problematic in pregnancy. We report a case...
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Severe Hypogammaglobulinemia Associated with Active Lupus Nephritis Treatment Resulting in Cytomegalovirus Infection

Chung MK, Kang Y, Lee J

Patients with severe active lupus nephritis (LN) require immunosuppressive therapy to induce remission. However, the development of profound hypogammaglobulinemia causing cytomegalovirus (CMV) disease is a rare occurrence during standard immunotherapy....
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Comparison of Renal Responses to Cyclophosphamide and Mycophenolate Mofetil used as Induction Therapies in Korean Patients with Lupus Nephritis

Choi SE, Park DJ, Kang JH, Lee KE, Xu H, Lee JS, Choi YD, Lee SS

OBJECTIVE: Although intravenous cyclophosphamide (IVC) is generally accepted as the standard therapy for induction treatment of active proliferative lupus nephritis (LN), several clinical trials have suggested that mycophenolate mofetil (MMF)...
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Self-Reported Physical Activity Is Associated with Lupus Nephritis in Systemic Lupus Erythematosus: Data from KORean Lupus Network (KORNET) Registry

Kim SK, Choe JY, Lee SS

PURPOSE: The aim of this study was to identify the associations among physical activity, disease activity, and organ damage in patients with systemic lupus erythematosus (SLE). MATERIALS AND METHODS: A total...
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Wolves Trapped in the NETs–The Pathogenesis of Lupus Nephritis

Kim Y, Shim SC

Systemic lupus erythematous (SLE) is a systemic autoimmune disease with multi-organ inflammation caused by the production of pathogenic autoantibodies and immune complexes reflecting a global loss of tolerance. Lupus nephritis...
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New insights into the role of renal resident cells in the pathogenesis of lupus nephritis

Kwok SK, Tsokos GC

Systemic lupus erythematosus (SLE), an autoimmune disease of unknown etiology, is characterized by the production of autoantibodies and end-organ damage. Lupus nephritis affects up to 70% of patients with SLE...
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Urinary Tumor Necrosis Factor-like Weak Inducer of Apoptosis as a Biomarker for Lupus Nephritis: A Meta-analysis

Lee YH, Song GG

OBJECTIVE: This study evaluates serum or urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) as a biomarker for lupus nephritis (LN). METHODS: We conducted a meta-analysis examining serum or urinary...
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Treatment with Allogenic Mesenchymal Stromal Cells in a Murine Model of Systemic Lupus Erythematosus

Tani C, Vagnani S, Carli L, Querci F, Kühl AA, Spieckermann S, Cieluch CP, Pacini S, Fazzi R, Mosca M

OBJECTIVE: Pre-clinical and uncontrolled studies in patients with systemic lupus erythematosus (SLE) showed that mesenchymal stromal cells (MSCs) have a potential therapeutic role in refractory cases. The optimal therapeutic strategy...
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Evaluating the association of interleukin-10 gene promoter -592 A/C polymorphism with lupus nephritis susceptibility

Abdallah E, Waked E, Abdelwahab MA

BACKGROUND: Interleukin-10 (IL-10) is an important immunoregulatory cytokine. There are few studies evaluating the association between IL-10 and lupus nephritis (LN). The aim of this study was to evaluate the...
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Non-bullous Neutrophilic Dermatosis in a Patient with Lupus Nephritis

Lee HJ, Kim JM, Kim GW, Moon JH, Kim HS, Ko HC, Kim BS, Kim MB, Song M

  • KMID: 2368894
  • Korean J Dermatol.
  • 2016 Dec;54(10):807-810.
Neutrophilic infiltrates of skin in the setting of lupus patients with bullous systemic lupus erythematosus (SLE) and leukocytoclastic vasculitis are well documented. However, most dermatology studies do not consider cutaneous...
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Lupus-like Glomerulonephritis Associated with Extranodal Marginal Zone B-cell Lymphoma of MALT

Kim EC, Lee HS, Lim YS, Lee JH, Oh SY, Lee HS, Kim MY

Lupus-like glomerulonephritis is an immune complex disease with features of lupus nephritis in the absence of systemic lupus erythematosus (SLE). We report a 49-year-old man diagnosed with lupus-like glomerulonephritis associated...
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Overview of IgG4-Related Tubulointerstitial Nephritis and Its Mimickers

Jeong HJ, Shin SJ, Lim BJ

Tubulointerstitial nephritis (TIN) is the most common form of renal involvement in IgG4-related disease. It is characterized by a dominant infiltrate of IgG4-positive plasma cells in the interstitium and storiform...
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Symmetrical Peripheral Gangrene Complicating Escherichia coli Sepsis Associated with Antiphospholipid Antibodies in Lupus Nephritis

Lee JS, Seong JS, Woo YM, Cho YJ, Jeong BJ, Kang HN, Kim SJ

Antiphospholipid syndrome (APS) is an autoimmune disease that involves vascular thrombosis and pregnancy morbidity associated with elevated titers of antiphospholipid antibodies. APS can affect any organ and has a variety...
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A Case of "Full-house" Nephropathy in a Non-lupus Patient

Yoo HY, Son M, Cho MH, Kwak BO, Park HW, Lim SD, Chung S, Kim KS

Histopathologic evidence of "full-house" immune complex deposits is a pathognomonic feature of lupus nephritis. This report presents the case of a 12-year-old boy with persistent microscopic hematuria and proteinuria. He...
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Diagnosis and Treatment of Lupus Nephritis: Survey Results on Four Important Issues

Joo YB, Sung YK, Park YB, Suh CH, Shim SC, Lee YH, Lee J, Lee HS, Cha HS, Bae SC

OBJECTIVES: To investigate the perception of and treatment pattern with regard to the four important issues in the management of lupus nephritis (LN), and to identify which parts of the...
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A Case of Systemic Lupus Erythematosus Occurring after H1N1 Influenza Vaccination

Jo SM, Shin JH, Bang KT, Jeong JU, Kim NM, Choi JW, Kim JH

  • KMID: 2267894
  • Korean J Med.
  • 2013 Feb;84(2):295-298.
The recent worldwide outbreak of H1N1 has led to the universal administration of H1N1 influenza vaccination, including in South Korea. Several complications have been reported with use of H1N1 influenza...
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Laparoscopic biopsy-proven lupus nephritis in autosomal dominant polycystic kidney disease

Park JI, Lee H, An JN, Chin HJ, Kim S

  • KMID: 2224219
  • Kidney Res Clin Pract.
  • 2012 Sep;31(3):192-195.
A 48-year-old woman with autosomal dominant polycystic kidney disease (ADPKD) presented with generalized edema and arthralgia. She showed evidences of acute glomerulonephritis including nephrotic-ranged proteinuria. Because her serologic test results...
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Urinary Hypoxia-Inducible Factor-1alpha Levels Are Associated with Histologic Chronicity Changes and Renal Function in Patients with Lupus Nephritis

Ma C, Wei J, Zhan F, Wang R, Fu K, Wan X, Li Z

PURPOSE: Tubulointerstitial hypoxia in the kidney is considered a hallmark of injury and a mediator of the progression of tubulointerstitial fibrosis. Hypoxia-inducible factor-1alpha (HIF-1alpha), a master transcription factor in cellular...
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