Saf Health Work.  2023 Mar;14(1):118-123. 10.1016/j.shaw.2023.02.001.

The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat

• Esfahani M
• Rahbar AH
• Asl SS
• Bashirian S
• Moeini ESM
• Mehri F

• KMID: 2541283
• DOI: http://doi.org/10.1016/j.shaw.2023.02.001

Abstract

Background
Chronic exposure to silica is related with the provocation of an inflammatory response and oxidative stress mechanism. Vitamin D has multiple benefits in biological activities particularly respiratory system disease. Method In this research, 20 male Wistar rats were randomly allocated into four groups (5 rats /group) as follow: Group1 received saline as (negative control) group. The group 2 received a single IT instillation of silica (positive control) group; the group 3 was co-administrated with single IT silica and Vitamin D (20 mg/kg/day) daily for a period of 90 days. The rats of group 4 received Vitamin D daily for a period of 90 days.
Results
Silica significantly increased serum and lung total Oxidant Status (TOS). Meanwhile, silica reduced serum and lung total antioxidant capacity (TAC), GSH and tumor necrosis factor-α (TNF-a). Vitamin D treatment meaningfully reversed oxidative stress, antioxidants status and inflammatory response. Also, Vitamin D improved histopathological changes caused by silica.
Conclusion
These findings indicate that Vitamin D exerts protective effects against silica-induced lung injury. It seems that Vitamin D has potential use as a therapeutic object for silica induced lung injure.

Keyword

Silicosis; Vitamin D; Oxidative stress; Infl ammation; TNF a