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Protective effects of Populus tomentiglandulosa against cognitive impairment by regulating oxidative stress in an amyloid beta25–35 -induced Alzheimer's disease mouse model

Kwon YR, Kim JH, Lee S, Kim HY, Cho EJ

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is one of the most representative neurodegenerative disease mainly caused by the excessive production of amyloid beta (Aβ). Several studies on the antioxidant activity and protective effects...
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Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review

Khosla L, Gong S, Weiss JP, Birder LA

Purpose: To conduct a systematic review of preclinical and clinical peer-reviewed evidence linking alterations in oxidative stress biomarkers or outcome measures that were also prevalent in specific age-related lower urinary...
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Ethanol Extract of Chaenomeles sinensis Inhibits the Development of Benign Prostatic Hyperplasia by Exhibiting Anti-oxidant and Anti-inflammatory Effects

Kang JS, Zhao XY, Lee JH, Lee JS, Keum YS

Chaenomeles sinensis is known to inhibit the development and progression of many age-related diseases, but the underlying molecular mechanisms are largely unclear. In the present study, we observed that the...
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Evaluation of genotoxic and oxidative stress potential of Ajakanga Landfill Leachate in rats

Arojojoye OA, Nwaechefu OO, Nkwadinamor SC

Genotoxicity and oxidative stress potential of Ajakanga Landfill Leachate (ALL) were investigated in this study. Forty-two male albino rats of the Wistar strain (100 g and 150 g) were divided...
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Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease

Jung CY, Yoo TH

Although diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease eventually requiring chronic kidney replacement therapy, the prevalence of DKD has failed to decline over the past...
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The Association between Serum Uric Acid and Relative Grip Strength: The 7th Korea National Health and Nutrition Examination Survey (2016‒2018)

Seo YB, Yoon YS

Purpose: Uric acid (UA) has both oxidative and antioxidant properties. The relationship between serum UA level and muscle strength is unclear. We aimed to investigate the relationship between serum UA...
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Comparison of the effects of coenzyme Q10 and Centrum multivitamins on semen parameters, oxidative stress markers, and sperm DNA fragmentation in infertile men with idiopathic oligoasthenospermia

Alahmar AT, Singh R

Objective: Oxidative stress and sperm DNA fragmentation (SDF) have been linked to idiopathic male infertility (IMI). Various antioxidants have been tried to improve semen parameters and fertility potential in IMI...
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The Association of COVID-19 and Reactive Oxygen Species Modulator 1 (ROMO1) with Oxidative Stress

Amini MA, Karimi J, Talebi SS, Piri H

There is no denying that the massive spread of COVID-19 around the world has worried everyone. The virus can cause mild to severe symptoms in various organs, especially the lungs....
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Antioxidant-Rich Dietary Intervention Improves Cardiometabolic Profiles and Arterial Stiffness in Elderly Koreans with Metabolic Syndrome

Chung HK, Kim JH, Choi A, Ahn CW, Kim YS, Nam JS

Purpose: Oxidative stress plays an important role in the pathogenesis of chronic metabolic diseases. This study investigated the effect of the antioxidant-rich dietary intervention on oxidative stress, metabolic parameters, and...
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Oxidative Stress: A Comprehensive Review of Biochemical, Molecular, and Genetic Aspects in the Pathogenesis and Management of Varicocele

Finelli R, Leisegang K, Kandil H, Agarwal A

Oxidative stress is a condition due to an imbalance between the concentrations of oxidants and antioxidants, and it is a wellrecognized contributor in several male infertility conditions. Varicocele, a common...
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Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines

Agarwal A, Farkouh A, Parekh N, Zini A, Arafa M, Kandil H, Tadros N, Busetto GM, Ambar R, Parekattil S, Boitrelle F, Sallam H, Jindal S, Ko E, Simopoulou M, Park HJ, Ali Sadighi M, Saleh R, Ramsay J, Martinez M, Elbardisi H, Alvarez J, Colpi G, Gosalvez J, Evenson D, Shah R

Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the...
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Suppressive effects of pectin on colitis-associated colon carcinogenesis

Yoo YJ, Kim HJ, Kim DH, Park YS, Nam SY, Lee BJ, Lee HJ

Colorectal cancer causes the most cancer-associated death worldwide, having a high cancer incidence. Pectin is a complex polysaccharide present in various fruits, emerging as an anti-carcinogenic candidate. Although pectin has...
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The antioxidant roles of L-carnitine and N-acetyl cysteine against oxidative stress on human sperm functional parameters during vitrification

Ghorbani F, Nasiri Z, Koohestanidehaghi Y, Lorian K

Objective: Amino acids can protect sperm structure in cryopreservation due to their antioxidant properties. Therefore, the present study aimed to investigate the protective effect of L-carnitine (LC) and N-acetyl cysteine...
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N-Acetyl cysteine mitigates histopathological changes and inflammatory genes expressions in the liver of cadmium exposed rats

Aala J, Harchegani AB, Monsef HA, Mohsenifar Z, Ebrahimi P, Parvizi MR

This study aimed to consider the expression of Nrf2, NLRP3 and caspase 1 genes, as well as oxidative stress, and the protective role of N-acetyl cysteine (NAC) in the liver...
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Schisandrae Fructus ethanol extract attenuates particulate matter 2.5-induced inflammatory and oxidative responses by blocking the activation of the ROS-dependent NFκB signaling pathway

Lee H, Park C, Kwon DH, Hwangbo H, Kim SY, Kim MY, Ji SY, Kim DH, Jeong JW, Kim GY, Hwang HJ, Choi YH

BACKGROUND/OBJECTIVES: Schisandrae Fructus, the fruit of Schisandra chinensis Baill., has traditionally been used as a medicinal herb for the treatment of various diseases, and has proven its various pharmacological effects,...
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Overexpression of SIRT3 Suppresses Oxidative Stress-induced Neurotoxicity and Mitochondrial Dysfunction in Dopaminergic Neuronal Cells

Lee S, Jeon YM, Jo M, Kim HJ

  • KMID: 2522147
  • Exp Neurobiol.
  • 2021 Oct;30(5):341-355.
  • doi: 10.5607/en21021
Sirtuin 3 (SIRT3), a well-known mitochondrial deacetylase, is involved in mitochondrial function and metabolism under various stress conditions. In this study, we found that the expression of SIRT3 was markedly...
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Deiodinases and the Three Types of Thyroid Hormone Deiodination Reactions

Sabatino L, Vassalle C, Del Seppia C, Iervasi G

Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity, which both preserves the circulating levels of the biologically active triiodothyronine (T3) and regulates TH homeostasis at the local...
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Testosterone Protects Pancreatic β-cells from Apoptosis and Stress-Induced Accelerated Senescence

Kang SM, Jung HS, Kwon MJ, Lee SH, Park JH

Purpose: Androgens are steroid hormones that are very important in the sexual development and the maintenance of male reproductive system, and also have diverse actions in non-reproductive tissues, including potent...
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Protective effects of folic acid on colon carcino-genesis induced by azoxymethane in mice

Sohn JY, Kim EY, Jeong JH, Kim DJ, Nam SY, Lee HJ, Lee BJ

Colon cancer has been considered a leading cause of cancer-associated death. Folic acid is a vitamin necessary for cellular physiological functions and cell viability. However, the association between folic acid...
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Zinc and selenium supplement mitigated valproic acid-induced testis toxicity by modulating the oxidative redox balance in male rats

Naderi M, Ahangar N, Badakhshan F, Ghasemi M, Shaki F

Valproic acid (VPA) is widely used antiepileptic agent which is associated with reproductive toxicity via impairment in oxidative redox. Zinc (Zn) and selenium (Se) are trace element with antioxidant effect...
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