Pediatr Gastroenterol Hepatol Nutr.  2023 Jan;26(1):34-42. 10.5223/pghn.2023.26.1.34.

Fecal Calprotectin Levels Significantly Correlate with Polyp Size in Children and Adolescents with Juvenile Colorectal Polyps

Affiliations
  • 1Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea
  • 2Department of Pediatrics, Eulji University Hospital, Daejeon, Korea
  • 3Department of Pediatrics, School of Medicine, Kyunpook National University, Daegu, Korea
  • 4Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea
  • 5Department of Pediatrics, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea
  • 6Department of Pediatrics, Jeonbuk National University Medical School and Hospital, Jeonju, Korea
  • 7Department of Pediatrics, Keimyung University School of Medicine, Dongsan Medical Center, Daegu, Korea
  • 8Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea
  • 9Department of Pediatrics, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Korea
  • 10Department of Pediatrics, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, Seoul, Korea
  • 11Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, Korea
  • 12Department of Pediatrics, Hallym University College of Medicine, Chuncheon, Korea

Abstract

Purpose
We aimed to investigate factors that correlate with fecal calprotectin (FC) levels in children and adolescents with colorectal polyps.
Methods
Pediatric patients aged <19 years who underwent colonoscopic polypectomy for a juvenile polyps (JPs) and FC tests were simultaneously conducted in a multicenter, retrospective study. Baseline demographics, colonoscopic and histological findings, and laboratory tests, including FC levels, were investigated. Correlations between the factors were investigated, and linear regression analysis revealed factors that correlated with FC levels. FC levels measured after polypectomies were investigated and the FC levels pre- and post-polypectomies were compared.
Results
A total of 33 patients were included in the study. According to Pearson correlation analysis, the polyp size was the only factor that showed a statistically significant correlation with FC levels (r=0.75, p<0.001). Furthermore, according to the multivariate linear regression analysis, polyp size was the only factor that showed a statistically significant correlation with FC levels (adjusted R2=0.5718, β=73.62, p<0.001). The median FC level was 400 mg/ kg (interquartile range [IQR], 141.6–1,000 mg/kg), and the median polyp size was 14 mm (IQR, 9–20 mm). Nineteen patients underwent post-polypectomy FC tests. FC levels showed a significant decrease after polypectomy from a median of 445.2 mg/kg (IQR, 225–1,000) to 26.5 mg/kg (11.5–51) ( p<0.001).
Conclusion
FC levels significantly correlated with polyp size in children and adolescents with JPs.

Keyword

Calprotectin; Juvenile polyp; Polyp size
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