J Korean Med Sci.  2022 Oct;37(41):e297. 10.3346/jkms.2022.37.e297.

Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea

Affiliations
  • 1Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
  • 2Division of Infectious Diseases, Department of Internal Medicine, Ajou University School of Medicine, Suwon, Korea
  • 3Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea
  • 4Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Korea
  • 5Division of Infectious Diseases, Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea
  • 6Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea
  • 7Division of Infectious Disease, Chungnam National University Sejong Hospital, Sejong, Korea
  • 8Department of Infectious Diseases, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea
  • 9Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Korea
  • 10Division of Infectious Diseases, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea
  • 11Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
  • 12Division of Infectious Diseases, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
  • 13Division of Infectious Disease, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
  • 14Division of Infectious Diseases, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
  • 15Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea
  • 16Division of Infectious Disease, Department of Internal Medicine, Seoul Medical Center, Seoul, Korea
  • 17Division of Infectious Disease, Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea
  • 18Department of Biostatistics, Korea University College of Medicine, Seoul, Korea

Abstract

Background
This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19.
Methods
This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021.
Results
A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04–1.15) and parity (OR, 1.703, 95% CI, 1.13–2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns’ amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2.
Conclusion
At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis.

Keyword

Severe Acute Respiratory Syndrome Coronavirus 2; Coronavirus Disease 2019; Pregnancy; Neonate

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