Ann Hepatobiliary Pancreat Surg.  2022 Aug;26(3):251-256. 10.14701/ahbps.21-151.

Clinical effect of preoperative intravenous non-steroidal anti-inflammatory drugs on relief of postoperative pain in patients after laparoscopic cholecystectomy: Intravenous ibuprofen vs. intravenous ketorolac

• Lee GG
• Park JS
• Kim HS
• Yoon DS
• Lim JH

• KMID: 2532641
• DOI: http://doi.org/10.14701/ahbps.21-151

Abstract

Backgrounds/Aims
Postoperative pain management is a key to enhanced recovery after surgery. The aim of this study was to evaluate clinical effect of preoperative intravenous (IV) non-steroidal anti-inf lammatory drugs (NSAIDs) on relief of postoperative pain in patients after laparoscopic cholecystectomy.
Methods
This single center, retrospective study was conducted between September 2019 and May 2020. A total of 163 patients were divided into two groups: Ibuprofen group The preoperative IV ibuprofen, n = 77) and Ketorolac group (preoperative IV ketorolac, n = 86). The primary outcome was postoperative pain score measured immediately in the recovery room.
Results
There was no difference in demographic characteristics between the two groups of patients. Postoperative pain score measured immediately in the recovery room was significantly higher in the Ibuprofen group than in the Ketorolac group (mean value: 5.09 vs. 4.61; p = 0.027). The number of patients who needed analgesics immediately in the recovery room was also higher in the Ibuprofen group than in the Ketorolac group (28 [36.4%] vs. 18 [20.9%]; p = 0.036).
Conclusions
In this study, preoperative IV injection with ketorolac reduced postoperative pain and analgesic requirement in the recovery room more effectively than that with ibuprofen. However, both showed similar effects on peak pain and pain at discharge. Numbers of patients requiring additional analgesics were also similar between the two groups.

Keyword

Postoperative pain; Anti-inf lammatory agents; non-steroidal; Ibuprofen; Ketorolac; Laparoscopic cholecystectomy

Figure

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  Fig. 1 Definition of ibuprofen group and ketorolac group. IVF, intravenous injection with fluid; IM, intramuscular; POD, postoperative day.

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  Fig. 2 Comparison of postoperative the visual analogue scale (VAS) score between the Ibuprofen group and the Ketorolac group.

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