J Dent Anesth Pain Med.  2018 Jun;18(3):161-167. 10.17245/jdapm.2018.18.3.161.

Effect of preemptive intravenous ibuprofen on postoperative edema and trismus in third molar tooth extraction: A randomized controlled study

• Gülnahar
• Kupeli I

• KMID: 2415180
• DOI: http://doi.org/10.17245/jdapm.2018.18.3.161

Abstract

BACKGROUND
This study aimed to evaluate the anti-inflammatory efficacy of preemptive intravenous ibuprofen on inflammatory complications such as edema and trismus in patients undergoing impacted mandibular third molar surgery.
METHODS
Sixty patients were included and divided into three groups (800 mg IV ibuprofen + 50 mg dexketoprofen, 800 mg IV ibuprofen, and control). In all patients, preoperative hemodynamic values were recorded before the infusions. The operation was started at 15-min post-infusion. Evaluation of edema size on the face and mouth opening (trismus) was conducted in the preoperative period, and at postoperative 48 h and 1 week.
RESULTS
No difference was determined among the groups in trismus and edema size in postoperative measurements (P > 0.05). There was a difference between group 2 and group 3 only in measurement value of tragus-corner of the mouth on the postoperative day 2 (P < 0.05). A difference was found between the measurement values of trismus preoperatively and at preoperative day 2, and between postoperative day 2 and 1 week in group 3 based on time (P < 0.05). In group 3, edema on the face on postoperative day 2 increased significantly compared to that in the preoperative period (P < 0.001); in addition, edema increased significantly in groups 1 and 2 in the postoperative period but was less than that in group 3 (P < 0.001).
CONCLUSIONS
In this study, intravenous ibuprofen was determined to be more effective alone or in combination in alleviating trismus and to better limit the postoperative edema.

Keyword

Edema; Postoperative; Preemptive Intravenous Ibuprofen; Third Molar; Tooth Extraction; Trismus

MeSH Terms

Edema*
Hemodynamics
Humans
Ibuprofen*
Molar, Third*
Mouth
Postoperative Period
Preoperative Period
Tooth Extraction*
Tooth*
Trismus*
Ibuprofen

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