J Korean Geriatr Psychiatry.  2022 Apr;26(1):12-17. 10.47825/jkgp.2022.26.1.12.

Reduced Volume of Anterior Corpus Callosum in Alzheimer’s Disease With Psychotic Symptoms: Cross-Sectional Magnetic Resonance Imaging Study

• Lee H
• Lee YM
• Park JM
• Lee BD
• Moon E
• Jeong HJ
• Suh H
• Kim K
• Kim HJ
• Park K
• Choi KU

• KMID: 2529488
• DOI: http://doi.org/10.47825/jkgp.2022.26.1.12

Abstract

Objective
Although previous studies have shown association between anterior corpus callosum (ACC) and various psychotic disorder, the effect of ACC on development on psychotic symptoms in Alzheimer’s disease (AD) is still unclear. The purpose of this study is to investigate the association of ACC with the development of psychosis in patients with AD.
Methods
This is a hospital based cross-sectional study of 241 AD patients. The main outcome measure is the volume of ACC that were measured as regions of interest with magnetic resonance imaging and the FreeSurfer analysis at baseline. Analysis of covariance and Logistic regression analysis conducted to assess the association between the volume of ACC and the presence of psychosis in AD, adjusting for age, education, Clinical Dementia Rating-Sum of Boxes, and total intracranial volume.
Results
We found that the volume of ACC is significantly reduced in AD with psychosis (AD+P) compared to AD without psychosis (AD-P) (774.27±142.96 vs. 833.09±142.04, p=0.005). The volume of ACC associated with the presence of psychosis in AD (odds ratio=0.995; 95% confidence interval=0.993-0.997; p=0.006).
Conclusion
We have found that reduced volume of ACC in AD+P, suggesting that ACC might play an important role in the underlying pathogenesis of development of psychotic symptoms in AD.

Keyword

Anterior corpus callosum; Psychosis; Alzheimer’s disease