J Korean Assoc Oral Maxillofac Surg.  2021 Dec;47(6):480-483. 10.5125/jkaoms.2021.47.6.480.

Autologous blood derived cell therapy in maxillofacial bone graft surgery

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University, Seoul, Korea

Abstract

Tissue regeneration is one of the ultimate goals of maxillofacial surgery and various types of tissue engineering technologies have been utilized in clinics. Healthy resources of host cells and growth factors are essential for the tissue engineering, therefore autologous blood-derived cell therapy was introduced. In this article, clinical applications of the autologous platelet concentrates and stem cell separation therapy will be summarized and evaluated for their efficacy and feasibility in the current maxillofacial clinics.

Keyword

Tissue engineering; Regeneration; Maxilla; Mandible; Autografts

Figure

  • Fig. 1 The layers after centrifugation, the blood components and separated cells are shown among PRP (platelet-rich plasma; the most left), PRF (platelet-rich fibrin; middle) and autologous bone marrow (BM) stem cell concentrate (the most right). The final product from each preparation method is written in blue.


Reference

References

1. Ceccarelli G, Presta R, Benedetti L, Cusella De Angelis MG, Lupi SM. Rodriguez Y Baena R. 2017; Emerging perspectives in scaffold for tissue engineering in oral surgery. Stem Cells Int. 2017:4585401. https://doi.org/10.1155/2017/4585401. DOI: 10.1155/2017/4585401. PMID: 28337223. PMCID: PMC5346390.
Article
2. Doonquah L, Holmes PJ, Ranganathan LK, Robertson H. 2021; Bone grafting for implant surgery. Oral Maxillofac Surg Clin North Am. 33:211–29. https://doi.org/10.1016/j.coms.2021.01.006. DOI: 10.1016/j.coms.2021.01.006. PMID: 33750652.
Article
3. Rakhmatia YD, Ayukawa Y, Furuhashi A, Koyano K. 2013; Current barrier membranes: titanium mesh and other membranes for guided bone regeneration in dental applications. J Prosthodont Res. 57:3–14. https://doi.org/10.1016/j.jpor.2012.12.001. DOI: 10.1016/j.jpor.2012.12.001. PMID: 23347794.
Article
4. Zhao R, Yang R, Cooper PR, Khurshid Z, Shavandi A, Ratnayake J. 2021; Bone grafts and substitutes in dentistry: a review of current trends and developments. Molecules. 26:3007. https://doi.org/10.3390/molecules26103007. DOI: 10.3390/molecules26103007. PMID: 34070157. PMCID: PMC8158510.
Article
5. Masoudi E, Ribas J, Kaushik G, Leijten J, Khademhosseini A. 2016; Platelet-rich blood derivatives for stem cell-based tissue engineering and regeneration. Curr Stem Cell Rep. 2:33–42. https://doi.org/10.1007/s40778-016-0034-8. DOI: 10.1007/s40778-016-0034-8. PMID: 27047733. PMCID: PMC4817373.
Article
6. Marx RE. 2004; Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 62:489–96. https://doi.org/10.1016/j.joms.2003.12.003. DOI: 10.1016/j.joms.2003.12.003. PMID: 15085519.
Article
7. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. 1998; Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 85:638–46. https://doi.org/10.1016/s1079-2104(98)90029-4. DOI: 10.1016/S1079-2104(98)90029-4.
Article
8. Xu J, Gou L, Zhang P, Li H, Qiu S. 2020; Platelet-rich plasma and regenerative dentistry. Aust Dent J. 65:131–42. https://doi.org/10.1111/adj.12754. DOI: 10.1111/adj.12754. PMID: 32145082. PMCID: PMC7384010.
Article
9. Miron RJ, Fujioka-Kobayashi M, Bishara M, Zhang Y, Hernandez M, Choukroun J. 2017; Platelet-rich fibrin and soft tissue wound healing: a systematic review. Tissue Eng Part B Rev. 23:83–99. https://doi.org/10.1089/ten.TEB.2016.0233. DOI: 10.1089/ten.teb.2016.0233. PMID: 27672729.
Article
10. Miron RJ, Zucchelli G, Pikos MA, Salama M, Lee S, Guillemette V, et al. 2017; Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clin Oral Investig. 21:1913–27. https://doi.org/10.1007/s00784-017-2133-z. DOI: 10.1007/s00784-017-2133-z. PMID: 28551729.
Article
11. Naik B, Karunakar P, Jayadev M, Marshal VR. 2013; Role of platelet rich fibrin in wound healing: a critical review. J Conserv Dent. 16:284–93. https://doi.org/10.4103/0972-0707.114344. DOI: 10.4103/0972-0707.114344. PMID: 23956527. PMCID: PMC3740636.
Article
12. Strauer BE, Brehm M, Zeus T, Gattermann N, Hernandez A, Sorg RV, et al. 2001; [Intracoronary, human autologous stem cell transplantation for myocardial regeneration following myocardial infarction]. Dtsch Med Wochenschr. 126:932–8. German. https://doi.org/10.1055/s-2001-16579-2. DOI: 10.1055/s-2001-16579-2. PMID: 11523014.
Article
13. Aktas M, Radke TF, Strauer BE, Wernet P, Kogler G. 2008; Separation of adult bone marrow mononuclear cells using the automated closed separation system Sepax. Cytotherapy. 10:203–11. https://doi.org/10.1080/14653240701851324. DOI: 10.1080/14653240701851324. PMID: 18368599.
Article
14. Güven S, Karagianni M, Schwalbe M, Schreiner S, Farhadi J, Bula S, et al. 2012; Validation of an automated procedure to isolate human adipose tissue-derived cells by using the Sepax® technology. Tissue Eng Part C Methods. 18:575–82. https://doi.org/10.1089/ten.TEC.2011.0617. DOI: 10.1089/ten.tec.2011.0617. PMID: 22372873. PMCID: PMC3401386.
Article
15. Mazzanti B, Urbani S, Dal Pozzo S, Bufano P, Ballerini L, Gelli A, et al. 2017; Fully automated, clinical-grade bone marrow processing: a single-centre experience. Blood Transfus. 15:577–84. https://doi.org/10.2450/2016.0057-16. DOI: 10.2450/2016.0057-16.
Article
16. Kobayashi E, Flückiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B, et al. 2016; Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 20:2353–60. https://doi.org/10.1007/s00784-016-1719-1. DOI: 10.1007/s00784-016-1719-1. PMID: 26809431.
Article
17. Cruz-Barrera M, Flórez-Zapata N, Lemus-Diaz N, Medina C, Galindo CC, González-Acero LX, et al. 2020; Integrated analysis of transcriptome and secretome from umbilical cord mesenchymal stromal cells reveal new mechanisms for the modulation of inflammation and immune activation. Front Immunol. 11:575488. https://doi.org/10.3389/fimmu.2020.575488. DOI: 10.3389/fimmu.2020.575488. PMID: 33117373. PMCID: PMC7561386.
Article
18. Li C, Li J, Li Y, Lang S, Yougbare I, Zhu G, et al. 2012; Crosstalk between platelets and the immune system: old systems with new discoveries. Adv Hematol. 2012:384685. https://doi.org/10.1155/2012/384685. DOI: 10.1155/2012/384685. PMID: 23008717. PMCID: PMC3447344.
Article
Full Text Links
  • JKAOMS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr