J Liver Cancer.  2021 Mar;21(1):69-75. 10.17998/jlc.21.1.69.

A Case of Lymphocyte-Rich Hepatocellular Carcinoma in a Patient Who Was Treated for Colon Cancer

  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
  • 2Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
  • 3Yonsei Liver Center, Severance Hospital, Seoul, Korea
  • 4Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
  • 5Department of Surgery, Yonsei University College of Medicine, Seoul, Korea


Hepatocellular carcinoma (HCC) primarily originates in the liver with hepatic differentiation. However, HCCs are not homogenous, and approximately 35% of HCC cases are classified as histopathological variants that present distinct pathologic characteristics. In particular, the lymphocyte-rich variant is the rarest subtype accounting for less than 1% of HCCs, which is not well known to date about molecular features and pathophysiology. Herein, we present a case of a patient who was suspected of metastatic liver cancer and confirmed as lymphocyte-rich HCC pathologically. A 78-year-old woman who underwent a right hemicolectomy for colon cancer was referred to our hospital for a newly detected liver mass. We could not make a decision because of insufficient evidence for diagnosis from imaging studies. After resection, we found that it was a lymphocyte-rich HCC. The pathologic features and prognostic trends of this subtype are also discussed.


Hepatocellular carcinoma; Hepatocellular carcinoma variants; Lymphocyte-rich subtype
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