J Liver Cancer.  2022 Sep;22(2):178-182. 10.17998/jlc.2022.06.10.

Fibrolamellar hepatocellular carcinoma that was successfully treated with surgical resection: a case report

• Na SK

• KMID: 2534244
• DOI: http://doi.org/10.17998/jlc.2022.06.10

Abstract

Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare malignant hepatic cancer with characteristics that differ from those of typical hepatocellular carcinoma (HCC). Unlike conventional HCC, FLHCC is common in young patients without any underlying liver disease and is known to be associated with a unique gene mutation. This cancer type is rare in Asia, with only a few cases being reported in Korea. We report a case of FLHCC in a young woman that successfully underwent surgical resection. The efficacy of alternative treatments, such as transarterial chemoembolization or systemic chemotherapies, has not yet been established. To conclude, early diagnosis and appropriate surgical resection are important for the treatment of FLHCC.

Keyword

Fibrolamellar hepatocellular carcinoma; Surgery; Therapy; Case report

Figure

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  Figure 1. A 13 cm lobulated liver mass with a suspicious central scar was shown on ultrasonography.

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  Figure 2. Liver dynamic magnetic resonance imaging showed 13 cm sized lobulated iso-signal intensity mass in the right anterior section with prominent arterial enhancement (A) and low signal intensity in delayed phase (B), defect in hepatobiliary phase (C), and a central scar on T2 weighted image (D).

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  Figure 3. Pathology image showed large polygonal cells with abundant eosinophilic cytoplasm; abundant fibrous stroma was arranged in thick, parallel lamellae (hematoxylin & eosin stain, ×100).

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