J Clin Neurol.  2021 Jan;17(1):63-69. 10.3988/jcn.2021.17.1.63.

Care Process of Recanalization Therapy for Acute Stroke during the COVID-19 Outbreak in South Korea

Affiliations
  • 1Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
  • 2Integrative Research Center for Cerebrovascular and Cardiovascular Diseases, Yonsei University College of Medicine, Seoul, Korea
  • 3Department of Neurology, Brain Research Institute, Keimyung University School of Medicine, Daegu, Korea
  • 4Department of Neurology, National Health Insurance Service Ilsan Hospital, Ilsan, Korea
  • 5Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 6Department of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea
  • 7Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea

Abstract

Background
and Purpose We aimed to determine whether the care process and outcomes in patients with acute stroke who received recanalization therapy changed during the outbreak of coronavirus disease 2019 (COVID-19) in South Korea.
Methods
We used data from a prospective multicenter reperfusion therapy registry to compare the care process including the time from symptom onset to treatment, number of treated patients, and discharge disposition and treatment outcomes between before and during the COVID-19 outbreak in South Korea.
Results
Upon the COVID-19 outbreak in South Korea, the number of patients receiving endovascular treatment to decrease temporarily but considerably. The use of emergency medical services by stroke patients increased from 91.5% before to 100.0% during the COVID-19 outbreak (p=0.025), as did the median time from symptom onset to hospital visit [median (interquartile range), 91.0 minutes (39.8–277.0) vs. 176.0 minutes (56.0–391.5), p=0.029]. Furthermore, more functionally dependent patients with disabilities were discharged home (59.5% vs. 26.1%, p=0.020) rather than staying in a regional or rehabilitation hospital. In contrast, there were no COVID-19-related changes in the times from the hospital visit to brain imaging and treatment or in the functional outcome, successful recanalization rate, or rate of symptomatic intracerebral hemorrhage.
Conclusions
These findings suggest that a prehospital delay occurred during the COVID-19 outbreak, and that patients with acute stroke might have been reluctant to visit and stay in hospitals. Our findings indicate that attention should be paid to prehospital care and the behavior of patients with acute stroke during the COVID-19 outbreak.

Keyword

reperfusion; therapy; stroke; outcome; coronavirus disease 2019
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