Gut Liver.  2020 Nov;14(6):707-726. 10.5009/gnl20246.

Clinical Guidelines for Drug-Related Peptic Ulcer, 2020 Revised Edition

  • 1Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
  • 2Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea
  • 3Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Korea
  • 4Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Korea
  • 5Department of Gastroenterology, Asan Medical Center, Asan Digestive Disease Research Institute, University of Ulsan College of Medicine, Seoul, Korea
  • 6Departments of Internal Medicine, Pusan National University School of Medicine, Busan, Korea
  • 7Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 8Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea
  • 9Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea
  • 10Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea
  • 11Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea


Korean guidelines for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer were previously developed in 2009 with the collaboration of the Korean College of Helico-bacter and Upper Gastrointestinal Research and Korean So-ciety of Gastroenterology. However, the previous guidelines were based mainly upon a review of the relevant literature and expert opinion. Therefore, the guidelines need to be revised. We organized a guideline Development Commit-tee for drug-related peptic ulcer under the auspices of the Korean College of Helicobacter and Upper Gastrointestinal Research in 2017 and developed nine statements, includ-ing four for NSAIDs, three for aspirin and other antiplatelet agents, and two for anticoagulants through a de novo process founded on evidence-based medicine that included a literature search and a meta-analysis, A consensus was reached through the application of the modified Delphi method. The primary target of these guidelines is adult pa-tients undergoing long-term treatment with NSAIDs, aspirin or other antiplatelet agents and anticoagulants. The revised guidelines reflect the expert consensus and is intended to assist clinicians in the management and prevention of druginduced peptic ulcer and associated conditions.


Peptic ulcer; Non-steroidal anti-inflammatory agents; Antiplatelet agent; Anticoagulants; Guideline
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