Endocrinol Metab.  2020 Jun;35(2):272-287. 10.3803/EnM.2020.35.2.272.

Diagnosis and Treatment of Growth Hormone Deficiency: A Position Statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology

Affiliations
  • 1Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine
  • 2Department of Pediatrics, Yonsei University College of Medicine
  • 3Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine
  • 4Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul
  • 5Division of Endocrinology and Metabolism, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang
  • 6Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea
  • 7Division of Geriatrics, Department of Internal Medicine, Yonsei University College of Medicine, Seoul
  • 8Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju
  • 9Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul
  • 10Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong
  • 11Department of Endocrinology, Inha University School of Medicine, Incheon
  • 12Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul
  • 13Department of Internal Medicine, National Cancer Center, Goyang
  • 14Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon
  • 15Department of Internal Medicine, Kosin University College of Medicine, Busan
  • 16Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon
  • 17Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju
  • 18Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju
  • 19Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul
  • 20Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon
  • 21Division of Endocrinology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan
  • 22Department of Internal Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon
  • 23Department of Endocrinology and Metabolism, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri
  • 24Division of Endocrinology, Department of Internal Medicine, Gachon University College of Medicine, Incheon
  • 25Department of Pediatrics, Seoul National University College of Medicine, Seoul
  • 26Division of Endocrinology and Metabolism, Department of Internal Medicine, Sejong General Hospital, Bucheon, Korea

Abstract

Growth hormone (GH) deficiency is caused by congenital or acquired causes and occurs in childhood or adulthood. GH replacement therapy brings benefits to body composition, exercise capacity, skeletal health, cardiovascular outcomes, and quality of life. Before initiating GH replacement, GH deficiency should be confirmed through proper stimulation tests, and in cases with proven genetic causes or structural lesions, repeated GH stimulation testing is not necessary. The dosing regimen of GH replacement therapy should be individualized, with the goal of minimizing side effects and maximizing clinical improvements. The Korean Endocrine Society and the Korean Society of Pediatric Endocrinology have developed a position statement on the diagnosis and treatment of GH deficiency. This position statement is based on a systematic review of evidence and expert opinions.

Keyword

Growth hormone; Dwarfism, pituitary; Hypopituitarism; Hormone replacement therapy
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