J Korean Med Sci.  2020 Apr;35(17):e148. 10.3346/jkms.2020.35.e148.

Association between ALDH2 Polymorphism and Gastric Cancer Risk in a Korean Population

Affiliations
  • 1Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Korea
  • 2Department of Hemato-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea
  • 3Gwangju-Jeonnam Regional Cardiocerebrovascular Center, Chonnam National University Hospital, Gwangju, Korea

Abstract

The association between alcohol and gastric cancer is stronger in East Asians than in other ethnic groups, presumably due to an aldehyde dehydrogenase 2 (ALDH2) polymorphism. Therefore, we investigated the relationship between the ALDH2 rs671 polymorphism and gastric cancer in a Korean population. This case-control study included 3,245 hospital patients newly diagnosed with gastric cancer and 8,732 population controls. The ALDH2 rs671 genotype was classified as inactive ALDH2 (GG) or active ALDH2 (GA/AA). The risk of gastric cancer was higher in men with the inactive ALDH2 than in those with active ALDH2 (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.09–1.39), whereas no significant association was found between ALDH2 genotype and gastric cancer in women (OR, 1.00; 95% CI, 0.99–1.02). In men, the association between ALDH2 genotype and gastric cancer was stronger in current drinkers. Our findings support the previously reported association between inactive ALDH2 and high risk of gastric cancer.

Keyword

Gastric Cancer; Alcohol Drinking; ALDH2
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