J Dig Cancer Rep.  2020 Dec;8(2):97-101.

The Metformin Use and Gastric Cancer Risk

Affiliations
  • 1Center for Gastric Cancer, National Cancer Center, Goyang, Korea

Abstract

Metformin is a widely used first-line anti-diabetic drug worldwide. Epidemiologic studies using the large population-based cohort database have shown the association between metformin uses and reduced risk of various type cancers including gastric cancer. In the gastric cancer prevention, metformin use was associated with the significant reduction of gastric cancer risk, especially for long-term metformin users. However, there is no well-designed randomized controlled clinical trial investigating the effect of metformin as a chemopreventive drug for gastric cancer. Therefore, further well-designed clinical trials will be needed to implement metformin for chemoprevention of gastric cancer.

Keyword

Chemoprevention; Gastric cancer; Metformin
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