Int Neurourol J.  2013 Dec;17(4):168-173.

Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population

Affiliations
  • 1Department of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea. jhchung@khu.ac.kr
  • 2Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.
  • 3Development of Ginseng and Medical Plants Research Institute, Rural Administration, Eumseong, Korea.

Abstract

PURPOSE
Aldehyde dehydrogenase 2 (ALDH2) is a well-known gene involved in alcohol and aldehyde metabolism. Moreover, recent studies have reported associations between ALDH2 and age-related disorders. Benign prostate hyperplasia (BPH) is an age-related disorder and genetic factors may contribute to its onset. In this study, we investigated the association of a well-studied ALDH2 single nucleotide polymorphism (SNP), rs671, with the onset and clinical features of BPH.
METHODS
A total of 222 BPH patients and 214 control subjects were genotyped. The clinical features of the BPH patients (prostate volume, prostate-specific antigen level, and International Prostatic Symptom Score) were analyzed.
RESULTS
The results show that rs671 was only associated with the volume of BPH in genotype and allele frequencies (P<0.05).
CONCLUSION
We propose that rs671 is an Asian-specific SNP in ALDH2 that may affect the disease progression of BPH in the Korean population.

Keyword

Prostatic hyperplasia; Aldehyde dehydrogenase 2; Single nucleotide polymorphism

MeSH Terms

Aldehyde Dehydrogenase
Disease Progression
Gene Frequency
Genotype
Humans
Hyperplasia*
Metabolism
Polymorphism, Single Nucleotide*
Prostate*
Prostate-Specific Antigen
Prostatic Hyperplasia
Aldehyde Dehydrogenase
Prostate-Specific Antigen
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