J Korean Orthop Assoc.  1974 Dec;9(4):491-496. 10.4055/jkoa.1974.9.4.491.

A Case of Multiple Involvements of Histocytosis

• Lee YW
• Choi CS
• Shim WS
• Kim YJ
• Kim BJ
• Seo KY
• Lee DI

• KMID: 2471476
• DOI: http://doi.org/10.4055/jkoa.1974.9.4.491

Abstract

A case of multiple involvements of Histiocytosis in 1 & 3/12-year-old male is reported. The patient was admitted with ohief complaints of diffuse swelling and tenderness on the left forearm. The diagnosis was confirmed by radiological evidence and biopsy findings. This initial lesio (left radius) was healed completely by curettage, but other lesions were missed. About seven months later, the patient was readimitted with chief complaits of swelling and terderness on the dorsum of the right hand. Radiographic examination revealed multiple skeletal involvements-humerus, clavicle, scapula, metacarpal, vertebrae, femur and pelvic bones which are similar findings with initial lesion. But classic triad of Hand Schüller-Christian Syndrome (skull defects, exophthalmos and diabeter insipidus) was not found. Second biopsy was carried out in the right second metacarpal bone and similar pathologic findings were also demonstrated. Some improvements were noted with steroid (prednisone). The patient is still alive well and follow-up studies are being continued. The review of literature was made briefly.

MeSH Terms

Biopsy
Clavicle
Curettage
Diagnosis
Exophthalmos
Femur
Follow-Up Studies
Forearm
Hand
Histiocytosis
Humans
Male
Pelvic Bones
Scapula
Spine

Reference

1. Cheyne C.Histiocytosis X. J. Bone and Joint Surg. 53-B:366. 1971.

2. Doede K.G., Rappaport H.Long-term survival of patients with acute differentiated histiocytosis (Letterer-Siwe disease). Cancer, 20. 1782, 1967. Quoted by Fritz Schajowicz;(1973).

3. Finzi: Quoted by Jaffe, H. L.Lichtenstein, L. (1944).

4. Fritz Schajowicz and Jorge Slulitel. Eosinophilic granuloma of bone and its relationship to Hand-Schüller-Christian and Letterer-Siwe Syndrome. J. Bone & Joint Surg. 55-B:545. 1973.

5. Galeotti-Flori A., Parenti G.G.Retiouloendotheliosi iperplasied ingettiva ad evoluzione, Granulo-xantomatosa (Tipo-Hand-Schüller-Christian). Rivistia di clinica pediatriea. 35:193. 1937; Quoted by Fritz Schajowicz. (1973).

6. Green W.T., Farber S.“Eosinophilic or solitary granuloma” of bone. J. Bone & Joint Surg. 24:499. 1942.

7. Fowles J.V., Bobechko W.P.. Solitary eosinophilic granuloma in bone. 52-3:238. 1970.

8. Jaffe H.L., Lichtenstein L.Eosinophlic granuloma of bone. A. M. A. Archives of Pathology. 37:99. 1944.

9. Lichtenstein L.Histiocytosis X. A. M. A. Archives of Pathology. 56:84. 1953.

10. Lichtenstein L.Histiocytosis Y. (Eosinophilic granuloma of bone, Letterer-Siwe disease, and Schüller-Christian disease). J. Bone & Joint Surg. 46-A:76. 1964.

11. Lichtenstein L., Jaffe H.L.Eosinophilic granuloma of bone. American Journal of Pathology. 16:595. 1940.

12. McGavran H.M., Spady H.A.Eosinophilic granuloma of bone. J. Bone & Joint Surg. 42-A:979. 1960.

13. Otani S., Ehrlich J.C.Solitary granuloma of bone simulating primary neoplasm. American Journal of Pathology. 16:479. 1940.

14. Schairer E.Ueber eine eigenartige Erkrankung des Kindlichen Schädels. Zentralblatt für allgemeine Pathologie und Pathologische Anatomie, 71;113, 1938. Quoted by Fritz Schajowicz et al. (1973).

15. Schajowicz F., Polak M.(1947); Quoted by Fritz Schajowicz. (1973).

16. Eosinophlic granuloma of bone. American J. of Roentgenology. 97:719. 1966.

17. Wallgren A.Systemic reticuloendothelial granuloma. American J. of diseases of children. 60:471. 1940.