Allergy Asthma Immunol Res.  2020 May;12(3):399-411. 10.4168/aair.2020.12.3.399.

Understanding the Molecular Mechanisms of Asthma through Transcriptomics

Affiliations
  • 1The Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA. restw@channing.harvard.edu
  • 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • 3Partners Center for Personalized Medicine, Partners Health Care, Boston, MA, USA.

Abstract

The transcriptome represents the complete set of RNA transcripts that are produced by the genome under a specific circumstance or in a specific cell. High-throughput methods, including microarray and bulk RNA sequencing, as well as recent advances in biostatistics based on machine learning approaches provides a quick and effective way of identifying novel genes and pathways related to asthma, which is a heterogeneous disease with diverse pathophysiological mechanisms. In this manuscript, we briefly review how to analyze transcriptome data and then provide a summary of recent transcriptome studies focusing on asthma pathogenesis and asthma drug responses. Studies reviewed here are classified into 2 classes based on the tissues utilized: blood and airway cells.

Keyword

Asthma; genetics; transcriptome; etiology
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