J Korean Radiol Soc.  1994 Apr;30(4):763-769.

Radiological Findings of Chronic Granulomatous Disease of Childhood

• Kim WS
• Goo JM
• Kim IO
• Yeon KM

Abstract

PURPOSE
Chronic granulomatous disease(CGD) is a group of genetic disorders characterized by recurrent pyogenic infections of the respiratory tract, skin,and soft tissue. The aim of this study is to describe the radiological findings of CGD.
MATERIALS AND METHODS
We retrospectively analyzed radiological findings of 11 patients of CGD, which were diagnosed by nitroblue tetrazolium test. We analyzed the pattern of pneumonia on chest radiograph in all infants. Three cases of chest CT and one case of digital subtraction angiography were performed. According to infant's symptom, abdominal ultrasonography(n=8), abdominal CT(n=5), simple bone radiography(n=2), and brain CT(n=I) were performed.
RESULTS
Repeated infiltration(100%), mass-like consolidation(73%), hilar or mediastinal lymph node enlargement(64%), scattered nodules(55%), cavity formation(27%), and pleural effusion(27%) were found on the chest radiographs(n=11) and CT(n=3). On the abdominal imagings(n=8), there were hepatosplenomegaly(n=6), calcifications in the liver(n=2) and kidney(n=1), hepatic granuloma(n=1) and renal abscess(n=1). Two patients had osteomyelitis. There were findings of meningitis on brain CT(n=1).
CONCLUSION
We believe that the combinations of these radiological findings may suggest the diagnosis of CGD in patients with history of reccurent infection.

MeSH Terms

Angiography, Digital Subtraction
Brain
Diagnosis
Granulomatous Disease, Chronic*
Humans
Infant
Lymph Nodes
Meningitis
Nitroblue Tetrazolium
Osteomyelitis
Pneumonia
Radiography, Thoracic
Respiratory System
Retrospective Studies
Thorax
Tomography, X-Ray Computed
Nitroblue Tetrazolium