Nucl Med Mol Imaging.  2019 Dec;53(6):432-435. 10.1007/s13139-019-00611-z.

Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT

Affiliations
  • 1Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India. nkantdamle@gmail.com, docsaurabharora@gmail.com, csbal@hotmail.com, kanaklata777@gmail.com, sneha.4teen@gmail.com, mynamedivya.1991@gmail.com, drmeivel@gmail.com
  • 2Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi 110029, India. dr.rachnameel@gmail.com
  • 3Department of Radio-diagnosis, All India Institute of Medical Sciences, New Delhi 110029, India. drssharma@hotmail.com
  • 4Department of Ocular Pathology, All India Institute of Medical Sciences, New Delhi 110029, India. drseemasen@gmail.com
  • 5All India Institute of Medical Sciences, New Delhi 110029, India.

Abstract

Immunoglobulin G4 (IgG4)-related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17:303-32, 2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 34:1812-9, 2010, Masaki et al. Ann Rheuma Dis 68:1310-5, 2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal glands, conjunctiva, eyelids, infraorbital nerve, orbital fat, and nasolacrimal system (McNab and McKelvie. Ophthal Plast Reconstr Surg 31:167-78, 2015, Katsura et al. Neuroradiology 54:873-82, 2012). The basis of using ⁶⁸Ga-DOTANOC PET/CT in IgG4 orbital disease is the known expression of somatostatin receptors in chronic inflammatory cells (Cuccurullo et al. Indian J Radiol Imaging 27:509-16, 2017) and also avidity shown previously in other IgG4-related diseases (Cheng et al. Clin Nucl Med 43:773-6, 2018).

Keyword

Orbital IgG4 disease; Somatostatin receptors; ⁶⁸Ga-DOTANOC PET/CT

MeSH Terms

Conjunctiva
Eyelids
Immunoglobulin G*
Immunoglobulins
Inflammation
Lacrimal Apparatus
Muscles
Orbit*
Orbital Diseases
Pancreatitis
Plasma Cells
Positron-Emission Tomography and Computed Tomography*
Receptors, Somatostatin
Immunoglobulin G
Immunoglobulins
Receptors, Somatostatin
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