J Korean Acad Oral Health.  2019 Dec;43(4):184-190. 10.11149/jkaoh.2019.43.4.184.

In vitro fluoride release from five different fluoride varnishes

  • 1Department of Preventive & Community Dentistry, School of Dentistry, Pusan National University, Yangsan, Korea. jsh0917@pusan.ac.kr


This study aims to compare the fluoride-release between different fluorine varnish under in vitro experimental conditions.
In this study, 5 fluoride varnish products distributed in Korea were selected. V-varnishâ„¢ (Vericom, Korea: VV), CavityShieldâ„¢ (3M ESPE, USA: CS), Clinproâ„¢ White varnishâ„¢ (3M ESPE, USA: CP), MI Varnishâ„¢ (GC, Japan: MI), and Fluor Protector (Ivoclar Vivadent, Liechtenstein: FP). For the in vitro study, 10 mg of each fluoride varnish was thinly applied to the same area of the specimen. The specimen was then immersed in 3 ml of distilled water at consistent intervals to confirm fluoride release. Nine specimens per group were used. Fluoride ion electrodes were used to measure the fluoride concentration of the solution. The Kruskal-Wallis nonparametric test was performed to compare between each experimental group, and the Wilcoxon signed-rank nonparametric test was performed to compare experimental groups over time. The significance level for a Type I error was set at 0.05. All statistical analyses were performed using SPSS 25.0 (IBM Co., Armonk, NY, USA).
In vitro experiments showed that the amount of fluoride released from MI was higher than the other groups during the first 12 hours after application. However, the amount of fluoride released from CP and CS was higher than MI as the immersion time increased over 12 and 20 hours, respectively. The fluoride release from FP was the lowest at all measurement points.
The results of this study showed that the remaining fluoride effect from rosin type fluoride varnishes was higher than liquid type fluoride varnishes. There were differences in the residual fluoride concentrations despite each fluoride varnish having the same fluoride content.


Dental caries; Fluoride release; Fluoride varnish; In vitro study
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