Korean Lepr Bull.  2019 Dec;52(1):3-8. 10.33161/klb.2019.52.1.3.

Cutaneous squamous cell carcinoma: High risk factors, staging and management

  • 1Department of Dermatology, Gachon University, Gil Medical Center, Korea. parkhjmd@gmail.com


Cutaneous squamous cell carconoma(cSCC) is a malignant neoplasm derived from suprabasal epidermal keratinocytes, which is one of the nonmelanoma skin cancers that represent the most common malignancies in humans. Although most of cSCCs are small low-risk cancers easily treated by minor surgical procedures, some cSCCs continue to grow to be invasive SCC. They can cause not only significant morbidity and cosmetic deformity but also even metastases and death. In leprosy, chronic, recurrent ulceration and resultant scars associated with peripheral neuropathy are one of the main complications, which can give rise to cSCCs. The primary goal of cSCC treatment is complete tumor eradication with preservation of function and good cosmesis. However, prior to treatment, the preoperative workup is performed properly and tumor risk factors influencing on the treatment and prognosis are taken into consideration.


Cutaneous squamous cell carcinoma; Leprosy; Tumor staging; Sentinel lymph node; Treatment

MeSH Terms

Carcinoma, Squamous Cell*
Congenital Abnormalities
Epithelial Cells*
Minor Surgical Procedures
Neoplasm Metastasis
Neoplasm Staging
Peripheral Nervous System Diseases
Risk Factors*
Skin Neoplasms


  • Fig. 1 Cutaneous SCCs developed in chronic, recurrent foot(sole and heel) ulcers in patients with leprosy.

  • Fig. 2 An example of treatment algorithm in cSCC(C&E:curettage & electrosurgery, SSE:standard surgical excision, POMA:postoperative margin assessment, Mohs:Mohs


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