J Korean Soc Biol Ther Psychiatry.  2019 Oct;25(3):251-256. 10.0000/jksbtp.2019.25.3.251.

Effect of Amyloid Deposition in PET on Hippocampal Metabolism in Amnestic-Mild Cognitive Impairment : Pilot Study

Affiliations
  • 1Department of Psychiatry, Pusan National University Hospital, Busan, Korea. psyleekr@naver.com
  • 2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
  • 3Department of Radiology, Pusan National University Hospital, Busan, Korea.
  • 4Department of Nuclear Medicine, Pusan National University Hospital, Busan, Korea.
  • 5School of Biomedical Engineering and u-HARC, Inje University, Gimhae, Korea.
  • 6Department of Psychiatry, Yangsan Pusan National University Hospital, Yangsan, Korea.

Abstract


OBJECTIVES
Most studies of hippocampal metabolism(HM) in amnestic mild cognitive impairment(aMCI) gave inconsistent results. Our objective was to evaluate the effect of amyloid-beta(Aβ) status on hippocampal metabolism in aMCI.
METHODS
Overall, 23 aMCI underwent three-dimensional magnetic resonance imaging(MRI), ¹â¸F-fluorodeoxyglucose-positron emission tomography(¹â¸FDG-PET) and ¹â¸F-Fluorbetaben amyloid positron emission tomography (amyloid-PET). According to Aβ status on amyloid PET, 23 aMCI were classified as either Aβ+aMCI(N=13) or Aβ−aMCI(N=10). The primary outcome was HM using ¹â¸FDG-PET and we investigate the difference on HM between Aβ+aMCI and Aβ−aMCI using analysis of variance(ANOVA) model, after controlling hippocampal volume.
RESULTS
We found that HM was more decreased in Aβ+aMCI than Aβ−aMCI. This result was not changed after controlling hippocampal volume.
CONCLUSION
Our findings suggest that Aβ+ is associated with decreased HM, regardless of hippocampal volume, in aMCI.

Keyword

Amyloid beta; Hippocampal metabolism; Amnestic mild cognitive impairment

MeSH Terms

Amyloid*
Cognition Disorders*
Metabolism*
Pilot Projects*
Plaque, Amyloid*
Positron-Emission Tomography
Amyloid
Full Text Links
  • JKSBTP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error