J Korean Geriatr Psychiatry.  2020 Apr;24(1):37-41.

Decreased Hippocampal Metabolism in Amnestic Mild Cognitive Impairment: Positron Emission Tomography Study

Affiliations
  • 1Departments of Psychiatry, Pusan National University Hospital, Busan, Korea
  • 2Departments of Medical Research Institute, Pusan National University Hospital, Busan, Korea
  • 3Departments of Radiology Pusan National University Hospital, Busan, Korea
  • 4Departments of Nuclear Medicine, Pusan National University Hospital, Busan, Korea
  • 5School of Biomedical Engineering and u-HARC, Inje University, Gimhae, Korea
  • 6Department of Psychiatry, Yangsan Pusan National University Hospital, Yangsan, Korea

Abstract


Objective
Little is known about factors influencing of hippocampal metabolism (HM) in mild cognitive impairment (MCI). Our objective was to determine whether HM in patients with amnestic MCI (aMCI) is decreased than non-amnestic MCI (naMCI).
Methods
Overall, 32 MCI patients underwent 18F-fluorodeoxyglucose-positron emission tomography. They were characterized as aMCI (n=18) or naMCI (n=14) according to comprehensive neuropsychological criteria. Analysis of variances were used to assess differences on HM between aMCI and naMCI after controlling age, sex, education and Korean version of Mini Mental Status Examination.
Results
We found that HM was more decreased in aMCI than naMCI. This result was not changed after controlling hippocampal volume.
Conclusion
Our findings suggest that aMCI is associated with decreased HM in MCI.

Keyword

Amnestic mild cognitive impairment; Hippocampal metabolism; Hippocampal volume
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