J Korean Radiol Soc.  1982 Mar;18(1):17-26. 10.3348/jkrs.1982.18.1.17.

An experimental study on the effect of 5-Thio-D-Glucose on radiation injury after hyperthermia

• Chang HS
• Han MC
• Kim CW
• Park CI

• KMID: 2463327
• DOI: http://doi.org/10.3348/jkrs.1982.18.1.17

Abstract

To evaluate the influence of 5-thio-D-glucose on irradiation effect after hyperthermia, an experimental study was carried out using a total of 72 mice. A single dose of 3000 rads was delivered on skin of mouse tail after hyperthermia with or without intraperitoneal injection of 5-thio-D-glucose 2 hours before irradiation. The hyperthermia was carried out at 43degrees C for 40 minutes just before the irradiation. The skin changes of their radiatied mouse tail were observed from 7th to 31st post-irradiation days, and the scores were anlayzed. Theresults are as follows; 1. Radiation damage on mouse skin increased significantly when radiation was combined withhyperthermia. 2. In the group of 5-thio-D-glucose and irradiation after hyperthermia, radiation damage on mouseskin significantly decreased than in the group without 5-thio-D-glucose. 3. 5-thio-D-glucose appears to be apotential radioprotective agent in clinical radiotherapy with hyperthermia.

MeSH Terms

Animals
Fever*
Injections, Intraperitoneal
Mice
Radiation Injuries*
Radiotherapy
Skin
Tail