Clin Exp Vaccine Res.  2019 Jul;8(2):136-139. 10.7774/cevr.2019.8.2.136.

Plant factory: new resource for the productivity and diversity of human and veterinary vaccines

• Shim BS
• Hong KJ
• Maharjan P
• Choe S

• KMID: 2455086
• DOI: http://doi.org/10.7774/cevr.2019.8.2.136

Abstract

Vaccination is one of the most successful strategies to prevent diseases caused by pathogens. Although various expression systems including Escherichia coli, yeast, insect, and mammalian cells are currently used for producing many of vaccines, these conventional platforms have the limitation of post-translational modification, high cost, and expensive scalability. In this respect, the plant-based expression system has been considered as an attractive platform to produce recombinant vaccines due to fast, cost-effective and scalable production as well as safety. This review discusses the development of plant-derived vaccines and the current stage of plant-based expression system.

Keyword

Transgenic plants; Vaccines; Pharmaceuticals; Antibodies

MeSH Terms

Antibodies
Efficiency*
Escherichia coli
Humans*
Insects
Plants*
Plants, Genetically Modified
Protein Processing, Post-Translational
Vaccination
Vaccines*
Vaccines, Synthetic
Yeasts
Antibodies
Vaccines
Vaccines, Synthetic