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Yonsei Med J.  2012 Sep;53(5):1049-1053.

Two Cases of Wernicke's Encephalopathy in Young Age Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation

Affiliations
  • 1Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • 2Division of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. cj@yuhs.ac

Abstract

Wernicke's encephalopathy is an acute neurolopsychiatric syndrome caused by thiamine deficiency, and classically presents with the triad of opthalmopathy, ataxia and altered mentality. Both prolonged total parenteral nutrition and reduced oral intake can induce Wernicke's encephalopathy during hematopoietic stem cell transplantation (HSCT). Although early treatment is important for recovery from Wernicke's encephalopathy, the vague symptoms and characteristics hinder early diagnosis. Furthermore, Wernicke's encephalopathy is not infrequent and can develop at any age during HSCT. Herein, we present two young patients developing Wernicke's encephalopathy during HSCT.

Keyword

Wernicke encephalopathy; thiamine; hematopoietic stem cell transplantation

MeSH Terms

Ataxia
Early Diagnosis
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells*
Humans
Parenteral Nutrition, Total
Thiamine
Thiamine Deficiency
Wernicke Encephalopathy*
Thiamine
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