Nat Prod Sci.  2019 Jun;25(2):143-149. 10.20307/nps.2019.25.2.143.

Enhanced Antioxidant and Anticancer Properties of Processed Eucommiae Cortex

Affiliations
  • 1Department of Natural Medicine Resources, Semyung University, Jecheon, Chungbuk 27136, Korea. hwalee@semyung.ac.kr
  • 2School of Industrial Bio-Pharmaceutical Science, Semyung University, Jecheon, Chungbuk 27136, Korea.

Abstract

Eucommiae Cortex (EC), bark of Eucommia ulmoides, has been known as a traditional medicine to regulate hypertension and immune system. Because silk of gum in the EC blocks the release of active ingredients, EC generally has been utilized after processing with carbonization or salt-water to breakdown it. This study aimed to investigate the differences of non-processed EC and processed EC on antioxidant and anticancer properties. Antioxidant capacity was assessed by measuring the content of total polyphenols, reducing power, and ABTS radical scavenging effect. And anticancer effects were examined by evaluating the viability of pancreatic cancer cells and wound healing ability. The results demonstrated that processed EC contained more content of polyphenols and exhibited more potent reducing power and radical scavenging effect than non-processed EC. In addition, processed EC more efficiently inhibited proliferation and migration of pancreatic cancer cells. These results suggest that processing of medicinal plants can improve the biological properties such as antioxidant or anticancer activity, which may lead to the development of herbal medicine treatment technology.

Keyword

Eucommia ulmoides; Processing; Antioxidant; Pancreatic cancer; Cell proliferation

MeSH Terms

Carbon
Cell Proliferation
Eucommiaceae
Gingiva
Herbal Medicine
Hypertension
Immune System
Medicine, Traditional
Pancreatic Neoplasms
Plants, Medicinal
Polyphenols
Silk
Wound Healing
Carbon
Polyphenols
Silk
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