J Bacteriol Virol.  2019 Jun;49(2):89-92. 10.4167/jbv.2019.49.2.89.

Role of Particulate Matter in Skin Inflammation

• Arooj M
• Koh YS

• KMID: 2452050
• DOI: http://doi.org/10.4167/jbv.2019.49.2.89

Abstract

Environmental pollution is a major global problem that affects human health. Among different types of environmental pollution, particulate matter (PM) has a key role. As PM spreads in the air so it causes different bronchial and skin inflammatory conditions. PM increases oxidative stress by ROS production and pro-inflammatory cytokines. As a result, matrix metalloproteinase is also produced, such as MMP1, MMP9 and MMP2 that is a known major cause of skin collagen degradation. Recently it has been shown that the PM worsens allergic conditions like dermatitis, psoriasis, and skin cancer. Different extensive efforts have been made across the globe to control this PM.

Keyword

Particulate matter; Pro-inflammatory cytokines

MeSH Terms

Collagen
Cytokines
Dermatitis
Environmental Pollution
Humans
Inflammation*
Oxidative Stress
Particulate Matter*
Psoriasis
Skin Neoplasms
Skin*
Collagen
Cytokines
Particulate Matter

Reference

1. Kim EK, Cho D, Park HJ. Air pollution and skin diseases: Adverse effects of airborne particulate matter on various skin diseases. Life Sci. 2016; 152:126–134.

2. Franck U, Odeh S, Wiedensohler A, Wehner B, Herbarth O. The effect of particule size on cardiovascular disorders—the smaller the worse. Sci Total Environ. 2011; 409:4217–4221.

3. Li N, Hao M, Phalen RF, Hinds WC, Nel AE. Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. Clin Immunol. 2003; 109:250–265.

4. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, et al. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect. 2003; 111:455–460.

5. Kappos AD, Bruckman P, Eikmann T, Englert N, Heinrich U, Hoppe P, et al. Health effects of particles in ambient air. Int J Hyg Environ Health. 2004; 207:399–407.

6. Kim J, Kim EH, Oh I, Jung K, Han Y, Cheong HK, et al. Symptoms of atopic dermatitis are influenced by outdoor air pollution. J Allergy Clin Immunol. 2013; 132:495–498.

7. Pappu R, Carrozzi VR, Ota N, Ouyang W, Hu Y. The IL-17 family cytokines in immunity and disease. J Clin Immunol. 2010; 30:185–195.

8. Jin SP, Li Z, Choi EK, Lee S, Kim YK, Seo EY, et al. Urban particulate matter in air pollution penetrates into the barrier-disrupted skin and produces ROS-dependent cutaneous inflammatory response in vivo. J Dermatol Sci. 2018; 91:175–183.

9. Kim YM, Kim J, Jung K, Eo S, Ahn K. The effects of particulate matter on atopic dermatitis symptoms are influenced by weather type: Application of spatial synoptic classification (SSC). Int J Hyg Environ Health. 2018; 221:823–829.

10. Pan TL, Wang PW, Aljuffali IA, Huang CT, Lee CW, Fang JY. The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption. J Dermatol Sci. 2015; 78:51–60.